Modulation of nutrient precursors for controlling metabolic inhibitors by genome‐scale flux balance analysis
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3313
Abstract: Therapeutic protein productivity and glycosylation pattern highly rely on cell metabolism. Cell culture medium composition and feeding strategy are critical to regulate cell metabolism. In this study, the relationship between toxic metabolic inhibitors and their… read more here.
Keywords: cell; cell metabolism; flux balance; nutrient precursors ... See more keywords
ClpXP affects the cell metabolism of Salmonella typhimurium partially in an RpoS-dependent manner
Sign Up to like & getrecommendations! Published in 2017 at "Metabolomics"
DOI: 10.1007/s11306-017-1296-6
Abstract: IntroductionClpXP protease is an important proteolytic system in Salmonella enterica serovar typhimurium (S. typhimurium). Inactivation of ClpXP by deletion of clpP resulted in overproduction of RpoS and a growth defect phenotype. Only one report has… read more here.
Keywords: rpos; salmonella; cell metabolism; clpp ... See more keywords
Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.05.040
Abstract: Cancer cell metabolism is quite different from normal cells. Targeting cancer metabolism and untuning the tumor metabolic machine has emerged as a promising strategy for cancer therapy. We have developed a multi-functional Re-dca conjugate (Re-dca… read more here.
Keywords: cancer; cancer cell; cell metabolism; dca ... See more keywords
Autophagy and T cell metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.01.033
Abstract: Autophagy, a highly conserved catabolic process that involves the degradation and recycling of intracellular components in the lysosome, has emerged as a key process in the maintenance of T cell homeostasis and the regulation of… read more here.
Keywords: autophagy cell; cell; cell metabolism;
Mechanisms linking mechanotransduction and cell metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.05.004
Abstract: Throughout their lifetimes, all cells experience force. These forces are sensed by cell surface adhesion receptors, such as the cadherins and integrins. Much attention has focused on identifying how these adhesion receptors transmit force. In… read more here.
Keywords: metabolism; cadherins integrins; cell metabolism; force ... See more keywords
System-level perturbations of cell metabolism using CRISPR/Cas9.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.03.014
Abstract: CRISPR/Cas9 (clustered regularly interspaced palindromic repeats and the associated protein Cas9) techniques have made genome engineering and transcriptional reprogramming studies more advanced and cost-effective. For metabolic engineering purposes, the CRISPR-based tools have been applied to… read more here.
Keywords: level perturbations; crispr cas9; system level; cell metabolism ... See more keywords
CALCIUM REGULATION OF T CELL METABOLISM.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in physiology"
DOI: 10.1016/j.cophys.2020.07.016
Abstract: T cells are an essential component of the immune system that provide antigen-specific acute and long lasting immune responses to infections and tumors, ascertain the maintenance of immunological tolerance and, on the flipside, mediate autoimmunity… read more here.
Keywords: calcium regulation; regulation cell; cell metabolism; cell ... See more keywords
The Molecular Link from Diet to Cancer Cell Metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.018
Abstract: Malignant cells remodel their metabolism to meet the demands of uncontrolled cell proliferation. These demands lead to differential requirements in energy, biosynthetic precursors, and signaling intermediates. Both genetic programs arising from oncogenic events and transcriptional… read more here.
Keywords: metabolism; cell metabolism; cancer cell; cell ... See more keywords
CO-mediated cytoprotection is dependent on cell metabolism modulation
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101470
Abstract: Carbon monoxide (CO) is a gasotransmitter endogenously produced by the activity of heme oxygenase, which is a stress-response enzyme. Endogenous CO or low concentrations of exogenous CO have been described to present several cytoprotective functions:… read more here.
Keywords: cytoprotection dependent; modulation; cell metabolism; mediated cytoprotection ... See more keywords
The roles of sirtuins family in cell metabolism during tumor development.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2018.11.003
Abstract: Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying have not been fully elucidated.… read more here.
Keywords: sirtuins family; metabolism; cell metabolism; roles sirtuins ... See more keywords
Subchronic Graphene Exposure Reshapes Skin Cell Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.2c00064
Abstract: In recent years, the toxicity of graphene-related materials (GRMs) has been evaluated in diverse models to guarantee their safety. In most applications, sublethal doses of GRMs contact human barriers such as skin in a subchronic… read more here.
Keywords: exposure reshapes; cell; cell metabolism; subchronic graphene ... See more keywords