Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115139119
Abstract: Significance Since sepsis induces a sustained immunosuppression responsible for secondary infections acquisition and late mortality, restoring immune function would result in a better outcome. Given the role of arginine deficiency in T cell dysfunction, the… read more here.
Keywords: sepsis; cell; function; cell mitochondrial ... See more keywords
Ubiquinol Supplementation of Donor Tissue Enhances Corneal Endothelial Cell Mitochondrial Respiration.
Sign Up to like & getrecommendations! Published in 2020 at "Cornea"
DOI: 10.1097/ico.0000000000002408
Abstract: PURPOSE To determine whether ubiquinol improves mitochondrial function and cell viability in human donor corneal endothelial cells during hypothermic corneal tissue storage. METHODS Endothelial cell Descemet membrane tissues were treated with 10 μM ubiquinol, the… read more here.
Keywords: cell mitochondrial; donor corneal; endothelial cell; corneal endothelial ... See more keywords
Single‐cell mitochondrial sequencing reveals low‐frequency mitochondrial mutations in naturally aging mice
Sign Up to like & getrecommendations! Published in 2024 at "Aging Cell"
DOI: 10.1111/acel.14242
Abstract: Mitochondria play a crucial role in numerous biological processes; however, limited methods and research have focused on revealing mitochondrial heterogeneity at the single‐cell level. In this study, we optimized the DNBelab C4 single‐cell ATAC (assay… read more here.
Keywords: mitochondrial sequencing; single cell; cell; mtscatac seq ... See more keywords
CDP-choline Corrects Alveolar Type II Cell Mitochondrial Dysfunction in Influenza-infected Mice.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0512oc
Abstract: Development of ARDS in influenza A virus (IAV)-infected mice is associated with inhibition of alveolar type II (ATII) epithelial cell de novo phosphatidylcholine synthesis and administration of the phosphatidylcholine precursor CDP-choline attenuates IAV-induced ARDS in… read more here.
Keywords: cdp choline; cell; cell mitochondrial; synthesis ... See more keywords
Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: evaluation in an immunocompetent model
Sign Up to like & getrecommendations! Published in 2025 at "Blood Advances"
DOI: 10.1182/bloodadvances.2024014822
Abstract: Key Points • Accumulation of defective depolarized mitochondria affects all T-cell subsets in CLL and is exacerbated during disease progression.• Ex vivo reprogramming of CLL T-cell mitochondrial activity enhances CAR T-cell efficacy and persistence in… read more here.
Keywords: car cell; cll; cell; model ... See more keywords
NK Cell Mitochondrial Membrane Potential-Associated Model Predicts Outcomes in Critically Ill Patients with COVID-19
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s458749
Abstract: Purpose This study investigated potential predictive models associated with natural killer (NK) cell mitochondrial membrane potential (MMP or ΔΨm) in predicting death among critically ill patients with COVID-19. Patients and Methods We included 97 patients… read more here.
Keywords: mitochondrial membrane; ill patients; patients covid; model ... See more keywords