Construction of a sensitive pyrogen‐testing cell model by site‐specific knock‐in of multiple genes
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27084
Abstract: A pyrogen test is crucial for evaluating the safety of drugs and medical equipment, especially those involved in injections. As existing pyrogen tests, including the rabbit pyrogen test, the limulus amoebocyte lysate (LAL) test and… read more here.
Keywords: pyrogen; knock; cell model; test ... See more keywords
The protection effects of survivin in the cell model of CVB3-induced viral myocarditis
Sign Up to like & getrecommendations! Published in 2020 at "Heart and Vessels"
DOI: 10.1007/s00380-020-01607-y
Abstract: Viral myocarditis (VMC) is a widely studied but poorly understood inflammatory cardiomyopathy which mainly affects children and young adults and results in adverse outcomes. Cardiomyocyte apoptosis was reported important in the progress of coxsackievirus B3… read more here.
Keywords: caspase; cvb3 induced; survivin; cell model ... See more keywords
Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-022-00918-7
Abstract: Cancer therapies with anthracyclines have been shown to induce cardiovascular complications. The aims of this study were to establish an in vitro induced pluripotent stem cell model (iPSC) of anthracycline-induced cardiotoxicity (ACT) from patients with… read more here.
Keywords: cell lymphoma; cell model; act; cell ... See more keywords
Simple Paper-based Liver Cell Model for Drug Screening
Sign Up to like & getrecommendations! Published in 2020 at "BioChip Journal"
DOI: 10.1007/s13206-020-4211-6
Abstract: Investigation of the potential adverse effects of chemicals and drugs is essential during the drug development process. In vitro cell model systems have been developed over the past years towards such toxicity investigation. 96-well plate… read more here.
Keywords: paper based; paper; cell model; drug ... See more keywords
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.03.030
Abstract: SUMMARY Interleukin-1β (IL-1β) is a key orchestrator of anti-microbial immunity whose secretion is typically dependent on activation of inflammasomes. However, many pathogens have evolved strategies to evade inflammasome activation. Here we describe an alternative, two-cell… read more here.
Keywords: model release; death receptor; cell model; two cell ... See more keywords
Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cell research"
DOI: 10.1016/j.scr.2017.11.009
Abstract: The cancer stem cell model postulates that tumors are hierarchically organized with a minor population, the cancer stem cells, exhibiting unlimited proliferative potential. These cells give rise to the bulk of tumor cells, which retain… read more here.
Keywords: cancer stem; cell model; proliferation; stem cell ... See more keywords
Biopharmaceutics classification evaluation for paris saponin VII.
Sign Up to like & getrecommendations! Published in 2020 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(20)60010-3
Abstract: To study the biopharmaceutics characteristics of paris saponin VII (PSVII). The solubility of PSVII was evaluated by measurement of the equilibrium solubility in different solvents and media. The permeability of PSVII was evaluated by measuring… read more here.
Keywords: mono layer; layer caco; cell model; psvii ... See more keywords
Spatial Analysis of Reactive Oxygen Species in a 3D Cell Model Using a Sensitive Nanocavity Electrode.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03444
Abstract: The analysis of biomolecules in a 3D cell model is crucial for the collection of spatial information close to the actual organ. In this work, a highly sensitive platinized open carbon nanocavity electrode is fabricated… read more here.
Keywords: nanocavity electrode; reactive oxygen; nanocavity; cell model ... See more keywords
Absorption rates and mechanism of avenanthramides in Caco-2 cell model and their antioxidant activity during absorption.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06576
Abstract: Avenanthramides (AVNs) were a unique kind of polyphenols which were only detected in the oats and have been demonstrated to exhibit strong antioxidant activities but low bioavailability. The purpose of the present research was to… read more here.
Keywords: absorption; avn avn; cell model; rates mechanism ... See more keywords
A Fissionable Artificial Eukaryote-like Cell Model.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b04009
Abstract: The use of artificial cells has attracted considerable attention in various fields from biotechnology to medicine. Here, we develop a cell-sized vesicle-in-vesicle (VIV) structure containing a separate inner vesicle (IV) that can be loaded with… read more here.
Keywords: fissionable artificial; like cell; cell model; eukaryote like ... See more keywords
Transcytosis of Bacillus subtilis extracellular vesicles through an in vitro intestinal epithelial cell model
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60077-4
Abstract: Bacterial EVs have been related to inter-kingdom communication between probiotic/pathogenic bacteria and their hosts. Our aim was to investigate the transcytosis process of B. subtilis EVs using an in vitro intestinal epithelial cell model. In… read more here.
Keywords: epithelial cell; intestinal epithelial; cell model; vitro intestinal ... See more keywords