Population Pharmacokinetic–B Cell Modeling for Ofatumumab in Patients with Relapsing Multiple Sclerosis
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DOI: 10.1007/s40263-021-00895-w
Abstract: Ofatumumab, a fully human anti-CD20 monoclonal antibody indicated for the treatment of relapsing forms of multiple sclerosis (RMS), binds to a unique conformational epitope, thereby depleting B cells very efficiently and allowing subcutaneous administration at… read more here.
Keywords: cell modeling; cell; population; effect ... See more keywords
Cell-to-cell modeling of the interface between atrial and sinoatrial anisotropic heterogeneous nets
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DOI: 10.1016/j.compbiolchem.2017.04.008
Abstract: The transition between sinoatrial cells and atrial cells in the heart is not fully understood. Here we focus on cell-to-cell mathematical models involving typical sinoatrial cells and atrial cells connected with experimentally observed conductance values.… read more here.
Keywords: cell modeling; modeling interface; sinoatrial cells; atrial sinoatrial ... See more keywords