In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-019-03846-x
Abstract: PurposeRecent researches are attempting to verify that the 3D cell models can provide a gap bridge between in vitro and in vivo for anticancer drug evaluations. The aim of this study was to continue the… read more here.
Keywords: cpt fl118; fl118 q20; cell; cell models ... See more keywords
Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2018.11.006
Abstract: OBJECTIVE To investigate interaction between autophagy and PKC-ε in lipid metabolism of NAFLD cell models. METHODS HL-7702 cells and SK-HEP-1 cells were cultured in vitro as NAFLD cell models and treated with RAPA to induce autophagy. 3-MA was… read more here.
Keywords: ratio induced; cell models; steatosis; induced autophagy ... See more keywords
Human stem cell models of polyglutamine diseases: Sources for disease models and cell therapy
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113573
Abstract: Polyglutamine (polyQ) diseases are a group of neurodegenerative disorders involving expanded CAG repeats in pathogenic genes that are translated into extended polyQ tracts and lead to progressive neuronal degeneration in the affected brain. To date,… read more here.
Keywords: stem cells; cell models; stem cell; therapy ... See more keywords
Investigating Leber's hereditary optic neuropathy: Cell models and future perspectives.
Sign Up to like & getrecommendations! Published in 2017 at "Mitochondrion"
DOI: 10.1016/j.mito.2016.11.006
Abstract: Leber's hereditary optic neuropathy (LHON) was the first human disease found to be associated with a mitochondrial DNA (mtDNA) point mutation. The most common LHON mutations are 11778G>A, 3460G>A or 14484T>C. The most common clinical… read more here.
Keywords: leber hereditary; cell models; hereditary optic; optic neuropathy ... See more keywords
γ-Oryzanol mitigates oxidative stress and prevents mutant SOD1-Related neurotoxicity in Drosophila and cell models of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107777
Abstract: Oxidative stress plays a critical role in mutant copper/zinc superoxide dismutase 1 (SOD1)-linked amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by selective loss of motor neurons. Thus, an anti-oxidative stress remedy might be… read more here.
Keywords: cell models; amyotrophic lateral; stress; drosophila cell ... See more keywords
Self-organized signaling in stem cell models of embryos
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.03.020
Abstract: Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental… read more here.
Keywords: self organized; cell models; models embryos; stem cell ... See more keywords
Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines
Sign Up to like & getrecommendations! Published in 2017 at "Xenobiotica"
DOI: 10.1080/00498254.2016.1211774
Abstract: Abstract 1. Cell models expressing human drug transporters and enzymes are useful tools to understand the process of drug disposition in vitro. However, no study on transfected cells stably co-expressing human organic anion transporter 1 (hOAT1)… read more here.
Keywords: hoat1 hcyp1a2; expressing human; cell models; hoat1 ... See more keywords
Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac121
Abstract: Kabuki syndrome (KS) is frequently caused by loss-of-function mutations in one allele of the H3K4 methyltransferase KMT2D and is associated with problems in neurological, immunological, and skeletal system development. We generated heterozygous KMT2D knock-out and… read more here.
Keywords: cell; stem cell; methyltransferase kmt2d; kmt2d ... See more keywords
Whole-Cell Models and Simulations in Molecular Detail.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-100617-062542
Abstract: Comprehensive data about the composition and structure of cellular components have enabled the construction of quantitative whole-cell models. While kinetic network-type models have been established, it is also becoming possible to build physical, molecular-level models… read more here.
Keywords: whole cell; cell models; biology; models simulations ... See more keywords
Abstract 6508: Eclipse, an automated CRISPR platform for the large-scale generation of cell models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6508
Abstract: Major advances in gene editing using CRISPR have improved accessibility for the creation of disease relevant in vitro models, allowing researchers to readily interrogate oncogenic driver mutations and elucidate novel targets to overcome challenges within… read more here.
Keywords: cell; platform; generation cell; cell models ... See more keywords
Abstract PD8-08: ESR1 mutations confer novel metastatic functions in genome-edited breast cancer cell models
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs17-pd8-08
Abstract: Background: Estrogen receptor alpha (ERα), encoded by the ESR1 gene, is expressed in approximately 70% of breast cancers. Recent studies conducted by us and others have shown that somatic mutations in ESR1 gene play a… read more here.
Keywords: cell models; breast cancer; cancer; cell ... See more keywords