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   Articles with "cell models" as a keyword



In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models

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recommendations! Published in 2019 at "Cancer Chemotherapy and Pharmacology"

DOI: 10.1007/s00280-019-03846-x

Abstract: PurposeRecent researches are attempting to verify that the 3D cell models can provide a gap bridge between in vitro and in vivo for anticancer drug evaluations. The aim of this study was to continue the… read more here.

Keywords: cpt fl118; fl118 q20; cell; cell models ... See more keywords

A robust multi-objective optimization algorithm for accurate parameter estimation for solar cell models

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recommendations! Published in 2024 at "Soft Computing"

DOI: 10.1007/s00500-024-09888-5

Abstract: The accuracy of solar cell models is crucial for enhancing the performance of solar photovoltaic (PV) systems. However, existing solar cell models lack precise parameters, and the manufacturer's datasheet does not provide the required information… read more here.

Keywords: accurate parameter; algorithm; cell models; cell ... See more keywords
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Roles of Autophagy and Protein Kinase C-epsilon in Lipid Metabolism of Nonalcoholic Fatty Liver Cell Models.

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recommendations! Published in 2018 at "Archives of medical research"

DOI: 10.1016/j.arcmed.2018.11.006

Abstract: OBJECTIVE To investigate interaction between autophagy and PKC-ε in lipid metabolism of NAFLD cell models. METHODS HL-7702 cells and SK-HEP-1 cells were cultured in vitro as NAFLD cell models and treated with RAPA to induce autophagy. 3-MA was… read more here.

Keywords: ratio induced; cell models; steatosis; induced autophagy ... See more keywords
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Human stem cell models of polyglutamine diseases: Sources for disease models and cell therapy

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recommendations! Published in 2021 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2020.113573

Abstract: Polyglutamine (polyQ) diseases are a group of neurodegenerative disorders involving expanded CAG repeats in pathogenic genes that are translated into extended polyQ tracts and lead to progressive neuronal degeneration in the affected brain. To date,… read more here.

Keywords: stem cells; cell models; stem cell; therapy ... See more keywords
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Investigating Leber's hereditary optic neuropathy: Cell models and future perspectives.

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recommendations! Published in 2017 at "Mitochondrion"

DOI: 10.1016/j.mito.2016.11.006

Abstract: Leber's hereditary optic neuropathy (LHON) was the first human disease found to be associated with a mitochondrial DNA (mtDNA) point mutation. The most common LHON mutations are 11778G>A, 3460G>A or 14484T>C. The most common clinical… read more here.

Keywords: leber hereditary; cell models; hereditary optic; optic neuropathy ... See more keywords

γ-Oryzanol mitigates oxidative stress and prevents mutant SOD1-Related neurotoxicity in Drosophila and cell models of amyotrophic lateral sclerosis

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recommendations! Published in 2019 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2019.107777

Abstract: Oxidative stress plays a critical role in mutant copper/zinc superoxide dismutase 1 (SOD1)-linked amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by selective loss of motor neurons. Thus, an anti-oxidative stress remedy might be… read more here.

Keywords: cell models; amyotrophic lateral; stress; drosophila cell ... See more keywords

Self-organized signaling in stem cell models of embryos

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recommendations! Published in 2021 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2021.03.020

Abstract: Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental… read more here.

Keywords: self organized; cell models; models embryos; stem cell ... See more keywords

A DIY Bioreactor for in Situ Metabolic Tracking in 3D Cell Models via Hyperpolarized 13C NMR Spectroscopy

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recommendations! Published in 2025 at "Analytical Chemistry"

DOI: 10.1021/acs.analchem.4c04183

Abstract: Nuclear magnetic resonance (NMR) spectroscopy is a valuable diagnostic tool limited by low sensitivity due to low nuclear spin polarization. Hyperpolarization techniques, such as dissolution dynamic nuclear polarization, significantly enhance sensitivity, enabling real-time tracking of… read more here.

Keywords: spectroscopy; hyperpolarized 13c; cell models; nmr spectroscopy ... See more keywords
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Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines

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recommendations! Published in 2017 at "Xenobiotica"

DOI: 10.1080/00498254.2016.1211774

Abstract: Abstract 1. Cell models expressing human drug transporters and enzymes are useful tools to understand the process of drug disposition in vitro. However, no study on transfected cells stably co-expressing human organic anion transporter 1 (hOAT1)… read more here.

Keywords: hoat1 hcyp1a2; expressing human; cell models; hoat1 ... See more keywords

Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).

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recommendations! Published in 2022 at "Human molecular genetics"

DOI: 10.1093/hmg/ddac121

Abstract: Kabuki syndrome (KS) is frequently caused by loss-of-function mutations in one allele of the H3K4 methyltransferase KMT2D and is associated with problems in neurological, immunological, and skeletal system development. We generated heterozygous KMT2D knock-out and… read more here.

Keywords: cell; stem cell; methyltransferase kmt2d; kmt2d ... See more keywords

A face‐to‐face comparison of the BBB cell models hCMEC/D3 and hBMEC for their applicability to adenoviral expression of transporters

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recommendations! Published in 2024 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.16125

Abstract: The blood–brain barrier (BBB) is a structure mainly formed by brain capillary endothelial cells (BCEC) whose role is to regulate the exchange of compounds between the blood and the brain. In this process efflux and… read more here.

Keywords: bbb cell; cell models; cell; expression ... See more keywords