Yeast‐derived vacuoles as a novel carrier with enhanced hCMEC/D3 cell monolayer penetration
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200393
Abstract: The blood–brain barrier (BBB) is a brain protection structure that restricts drug delivery from the blood to the central nervous system. Thus, we developed a novel drug carrier using yeast vacuoles to overcome this problem.… read more here.
Keywords: cell; drug; cell monolayer; hcmec cell ... See more keywords
The effect of lycopene on cytochrome P450 isoenzymes and P-glycoprotein by using human liver microsomes and Caco-2 cell monolayer model
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Food Sciences and Nutrition"
DOI: 10.1080/09637486.2017.1420756
Abstract: Abstract Lycopene is widely used as a dietary supplement. However, the effects of lycopene on cytochrome P450 (CYP) enzymes or P-glycoprotein (P-gp) are not comprehensive. The present study was performed to investigate the effects of… read more here.
Keywords: cell monolayer; lycopene cytochrome; effect; cytochrome p450 ... See more keywords
Deformation of a cell monolayer due to osmotic treatment: a case study of onion scale epidermis
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DOI: 10.1139/cjb-2019-0027
Abstract: We performed a combination of experiments and mechanical simulations to assess the importance of cell geometry and wall structure in tissue and cell mechanics. Osmotic treatments combined with live... read more here.
Keywords: deformation cell; due osmotic; monolayer due; cell ... See more keywords
An Experimental Workflow for Studying Barrier Integrity, Permeability, and Tight Junction Composition and Localization in a Single Endothelial Cell Monolayer: Proof of Concept
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DOI: 10.3390/ijms22158178
Abstract: Endothelial and epithelial barrier function is crucial for the maintenance of physiological processes. The barrier paracellular permeability depends on the composition and spatial distribution of the cell-to-cell tight junctions (TJ). Here, we provide an experimental… read more here.
Keywords: cell monolayer; experimental workflow; endothelial cell; cell ... See more keywords
In Vitro Study of the Bioavailability and Bioaccessibility of the Main Compounds Present in Ayahuasca Beverages
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DOI: 10.3390/molecules26185555
Abstract: Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of four individual… read more here.
Keywords: cell monolayer; bioavailability bioaccessibility; compounds present; main compounds ... See more keywords
Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity
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DOI: 10.3390/pharmaceutics13101563
Abstract: Caco-2 monolayers are a common in vitro model used to evaluate human intestinal absorption. The reference protocol requires 21 days post-seeding to establish a stable and confluent cell monolayer, which is used in a single… read more here.
Keywords: cell monolayer; monolayer; cell; caco monolayers ... See more keywords