Efficient Generation of Paired Single-Cell Multiomics Profiles by Deep Learning.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301169
Abstract: Recent advances in single-cell sequencing technology have made it possible to measure multiple paired omics simultaneously in a single cell such as cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) and single-nucleus chromatin accessibility… read more here.
Keywords: cell multiomics; cell; efficient generation; single cell ... See more keywords
JSNMF enables effective and accurate integrative analysis of single-cell multiomics data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac105
Abstract: The single-cell multiomics technologies provide an unprecedented opportunity to study the cellular heterogeneity from different layers of transcriptional regulation. However, the datasets generated from these technologies tend to have high levels of noise, making data… read more here.
Keywords: cell multiomics; jsnmf; cell; multiomics data ... See more keywords
scME: a dual-modality factor model for single-cell multiomics embedding
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad337
Abstract: Abstract Motivation Single-cell multiomics technologies are emerging to characterize different molecular features of cells. This gives rise to an issue of combining various kinds of molecular features to dissect cell heterogeneity. Most single-cell multiomics integration… read more here.
Keywords: cell multiomics; dual modality; cell; factor ... See more keywords
DIRECT-NET: An efficient method to discover cis-regulatory elements and construct regulatory networks from single-cell multiomics data
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl7393
Abstract: The emergence of single-cell multiomics data provides unprecedented opportunities to scrutinize the transcriptional regulatory mechanisms controlling cell identity. However, how to use those datasets to dissect the cis-regulatory element (CRE)–to–gene relationships at a single-cell level… read more here.
Keywords: cell multiomics; multiomics data; cell; direct net ... See more keywords
Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo5442
Abstract: Malignant peripheral nerve sheath tumor (MPNST), a highly aggressive Schwann cell (SC)–derived soft tissue sarcoma, arises from benign neurofibroma (NF); however, the identity, heterogeneity and origins of tumor populations remain elusive. Nestin+ cells have been… read more here.
Keywords: cell multiomics; cell; stem like; mesenchymal stem ... See more keywords
Single-Cell Multiomics Techniques: From Conception to Applications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.854317
Abstract: Recent advances in methods for single-cell analyses and barcoding strategies have led to considerable progress in research. The development of multiplexed assays offers the possibility to conduct parallel analyses of multiple factors and processes for… read more here.
Keywords: cell multiomics; cell; conception applications; techniques conception ... See more keywords
iPoLNG—An unsupervised model for the integrative analysis of single-cell multiomics data
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.998504
Abstract: Single-cell multiomics technologies, where the transcriptomic and epigenomic profiles are simultaneously measured in the same set of single cells, pose significant challenges for effective integrative analysis. Here, we propose an unsupervised generative model, iPoLNG, for… read more here.
Keywords: cell multiomics; multiomics data; cell; single cell ... See more keywords