A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M
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DOI: 10.1002/glia.24189
Abstract: Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are… read more here.
Keywords: diffuse midline; mouse; origin dependent; midline glioma ... See more keywords
Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.
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DOI: 10.1016/j.celrep.2016.12.059
Abstract: Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using progenitor cell-type-restricted adenoviral Cre… read more here.
Keywords: spectrum; cell origin; immune microenvironment; lkb1 ... See more keywords
FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice
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DOI: 10.1016/j.celrep.2020.02.052
Abstract: Summary Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other lung tumors has remained elusive. Here, we assess the tumorigenic capacity of… read more here.
Keywords: sclc; origin sclc; cell origin; fgfr1 ... See more keywords
aCLS cancers: genomic and epigenetic changes transform the cell of origin of cancer into a tumorigenic pathogen of unicellular organization and lifestyle.
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DOI: 10.1016/j.gene.2019.144174
Abstract: At least 1/3 of all acquired solid cancers produce unusual cyst-like structures (CLSs , PGCCs) with simultaneous loss of p53 function. However, p53 deficiency or accumulated mutations are not the causes of aCLS cancers. The… read more here.
Keywords: acls cancers; cell origin; origin cancer; cancer ... See more keywords
Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue
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DOI: 10.1038/s41598-020-64212-z
Abstract: Diffuse large B-cell lymphoma (DLBCL) is commonly classified by gene expression profiling according to its cell of origin (COO) into activated B-cell (ABC)-like and germinal center B-cell (GCB)-like subgroups. Here we report the application of… read more here.
Keywords: protein; cell; large cell; cell origin ... See more keywords
TBIO-09. IN SILICO ANALYSIS IDENTIFIES A PUTATIVE CELL-OF-ORIGIN FOR BRAF FUSION-POSITIVE CEREBELLAR PILOCYTIC ASTROCYTOMA
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DOI: 10.1093/neuonc/noaa222.837
Abstract: Abstract Childhood cancers are increasingly recognized as disorders of cellular development. This study sought to identify the cellular and developmental origins of cerebellar pilocytic astrocytoma, the most common brain tumor of childhood. By leveraging publicly… read more here.
Keywords: pilocytic astrocytoma; astrocytoma; ventricular zone; cell origin ... See more keywords
OS01.1 Identification of the pre-malignant cell of origin in Human Glioblastoma Multiforme.
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DOI: 10.1093/neuonc/nox036.000
Abstract: AbstractOne of the major difficulties in identifying the cell of origin for glioblastoma is the complex cellular composition of this disease. It is now hypothesized that the different subtypes of high-grade glioma may have different… read more here.
Keywords: cell origin; stem; pre malignant; stem cells ... See more keywords
Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum
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DOI: 10.1111/imm.13483
Abstract: The relationship between macrophages of the peritoneal cavity and the adjacent omentum remains poorly understood. Here, we describe two populations of omental macrophages distinguished by CD102 expression and use an adoptive cell transfer approach to… read more here.
Keywords: cavity; peritoneal macrophages; peritoneal; cell origin ... See more keywords
Abstract B28: A cross-species enhancer activity analysis approach to identify the Ewing sarcoma cell of origin
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DOI: 10.1158/1538-7445.pedca19-b28
Abstract: Ewing sarcoma is a malignant bone and soft tissue tumor in children and adolescents. In 85% of all cases the formation of Ewing sarcoma is caused by a chromosomal translocation, leading to the expression of… read more here.
Keywords: cross species; sarcoma cell; cell origin; ewing sarcoma ... See more keywords
Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition.
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DOI: 10.1158/2159-8290.cd-19-1469
Abstract: The cell of origin of oncogenic transformation is a determinant of therapeutic sensitivity, but the mechanisms governing cell-of-origin-driven differences in therapeutic response have not been delineated. Leukemias initiating in hematopoietic stem cells (HSC) are less… read more here.
Keywords: sensitivity; apoptotic priming; cell origin; lsd1 inhibition ... See more keywords
Therapy Response and Outcome Explained by Leukemia Cell of Origin.
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DOI: 10.1158/2159-8290.cd-20-1080
Abstract: In this issue of Cancer Discovery, Cai and colleagues delineate a new mechanism that links cell of origin, the transcription factor EVI1, apoptotic priming, and therapeutic susceptibility in mixed lineage leukemia-rearranged acute myeloid leukemia. These… read more here.
Keywords: cell origin; leukemia; outcome explained; therapy response ... See more keywords