A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M
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DOI: 10.1002/glia.24189
Abstract: Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are… read more here.
Keywords: diffuse midline; mouse; origin dependent; midline glioma ... See more keywords
Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.
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DOI: 10.1016/j.celrep.2016.12.059
Abstract: Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic heterogeneity following conditional expression of KrasG12D and loss of Lkb1 (Kras;Lkb1). Using progenitor cell-type-restricted adenoviral Cre… read more here.
Keywords: spectrum; cell origin; immune microenvironment; lkb1 ... See more keywords
FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice
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DOI: 10.1016/j.celrep.2020.02.052
Abstract: Summary Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other lung tumors has remained elusive. Here, we assess the tumorigenic capacity of… read more here.
Keywords: sclc; origin sclc; cell origin; fgfr1 ... See more keywords
aCLS cancers: genomic and epigenetic changes transform the cell of origin of cancer into a tumorigenic pathogen of unicellular organization and lifestyle.
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DOI: 10.1016/j.gene.2019.144174
Abstract: At least 1/3 of all acquired solid cancers produce unusual cyst-like structures (CLSs , PGCCs) with simultaneous loss of p53 function. However, p53 deficiency or accumulated mutations are not the causes of aCLS cancers. The… read more here.
Keywords: acls cancers; cell origin; origin cancer; cancer ... See more keywords
Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue
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DOI: 10.1038/s41598-020-64212-z
Abstract: Diffuse large B-cell lymphoma (DLBCL) is commonly classified by gene expression profiling according to its cell of origin (COO) into activated B-cell (ABC)-like and germinal center B-cell (GCB)-like subgroups. Here we report the application of… read more here.
Keywords: protein; cell; large cell; cell origin ... See more keywords
Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms
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DOI: 10.1038/s41598-024-62927-x
Abstract: Pleomorphic dermal sarcomas are infrequent neoplastic skin tumors, manifesting in regions of the skin exposed to ultraviolet radiation. Diagnosing the entity can be challenging and therapeutic options are limited. We analyzed 20 samples of normal… read more here.
Keywords: analysis; cell origin; cell; pleomorphic dermal ... See more keywords
TBIO-09. IN SILICO ANALYSIS IDENTIFIES A PUTATIVE CELL-OF-ORIGIN FOR BRAF FUSION-POSITIVE CEREBELLAR PILOCYTIC ASTROCYTOMA
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DOI: 10.1093/neuonc/noaa222.837
Abstract: Abstract Childhood cancers are increasingly recognized as disorders of cellular development. This study sought to identify the cellular and developmental origins of cerebellar pilocytic astrocytoma, the most common brain tumor of childhood. By leveraging publicly… read more here.
Keywords: pilocytic astrocytoma; astrocytoma; ventricular zone; cell origin ... See more keywords
OS01.1 Identification of the pre-malignant cell of origin in Human Glioblastoma Multiforme.
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DOI: 10.1093/neuonc/nox036.000
Abstract: AbstractOne of the major difficulties in identifying the cell of origin for glioblastoma is the complex cellular composition of this disease. It is now hypothesized that the different subtypes of high-grade glioma may have different… read more here.
Keywords: cell origin; stem; pre malignant; stem cells ... See more keywords
Cell of Origin of Pancreatic cancer
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DOI: 10.1097/mpa.0000000000002301
Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal diseases globally, boasting a grim 5-year survival prognosis. The origin cell and the molecular signaling pathways that drive PDAC progression are not entirely… read more here.
Keywords: cell origin; cell; origin pancreatic; pancreatic cancer ... See more keywords
Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum
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DOI: 10.1111/imm.13483
Abstract: The relationship between macrophages of the peritoneal cavity and the adjacent omentum remains poorly understood. Here, we describe two populations of omental macrophages distinguished by CD102 expression and use an adoptive cell transfer approach to… read more here.
Keywords: cavity; peritoneal macrophages; peritoneal; cell origin ... See more keywords
Neurolymphomatosis of T‐Cell Origin in a Dog
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DOI: 10.1111/jvim.70189
Abstract: A 10‐year‐old mixed‐breed dog was presented with progressive neurological deficits suggestive of polyneuropathy. CT and MRI revealed no relevant abnormalities, whereas the CSF analysis showed a marked lymphocytic pleocytosis, immunocytochemically classified as T‐cell lymphoma. Chemotherapy… read more here.
Keywords: cell origin; origin dog; neurolymphomatosis cell; cell ... See more keywords