Novel Small Molecule MEK Inhibitor URML-3881 Enhances Cisplatin Sensitivity in Clear Cell Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.04.009
Abstract: Advanced clear cell ovarian cancer (CCOC) is a highly fatal malignancy with a scarcity of effective treatment options. CCOC is inherently chemotherapy resistance, but the exact mechanism of this resistance has yet to be established.… read more here.
Keywords: urml 3881; inhibition; ovarian cancer; cancer ... See more keywords
Clear Cell Ovarian Cancer: Optimum Management and Prognosis Remain Hazy.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.10.012
Abstract: Epithelial ovarian cancer consists of several histological subtypes including low versus high grade serous, clear cell, endometrioid, and mucinous adenocarcinomas. These cell types have different patient demographics, carcinogenesis, molecular alterations, clinical presentations and prognoses [1].… read more here.
Keywords: ovarian cancer; cancer; oncology; clear cell ... See more keywords
A case report of small cell ovarian neuroendocrine carcinoma combined with immunochemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031445
Abstract: Background: Small cell ovarian neuroendocrine (NE) carcinoma is a rare NE tumor with a low incidence, poor prognosis, and no standardized treatment. To date, there have been no clear reports on the efficacy or prognosis… read more here.
Keywords: small cell; neuroendocrine carcinoma; ovarian neuroendocrine; cell ovarian ... See more keywords
Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-2674
Abstract: We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology indication may represent potential therapeutic targets. To test this hypothesis, we performed genome-scale… read more here.
Keywords: clear cell; cancer; egln1 dependency; cell ... See more keywords
Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes
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DOI: 10.1158/1078-0432.ccr-21-3817
Abstract: Abstract Purpose: To identify molecular subclasses of clear cell ovarian carcinoma (CCOC) and assess their impact on clinical presentation and outcomes. Experimental Design: We profiled 421 primary CCOCs that passed quality control using a targeted… read more here.
Keywords: molecular subclasses; cell ovarian; clear cell; ovarian carcinoma ... See more keywords
The Tumor Microenvironment of Clear-Cell Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0407
Abstract: The tumor microenvironment (TME) of clear cell ovarian cancer is characterized. Immune infiltration and collagen deposition differ based on disease stage, TME localization, and ARID1A status, highlighting the necessity of evaluating multiple features when determining… read more here.
Keywords: ovarian cancer; cell ovarian; tumor microenvironment; clear cell ... See more keywords
Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Oncology"
DOI: 10.2139/ssrn.3377550
Abstract: Background Granulosa cell ovarian tumor (GCT) is characterized by a pathognomonic mutation in the FOXL2 gene (402 C > G) that leads to an overactivation of steroidogenesis. CYP17 is a key enzyme in such process and can… read more here.
Keywords: oncology; cell ovarian; trial; granulosa cell ... See more keywords