Novel Small Molecule MEK Inhibitor URML-3881 Enhances Cisplatin Sensitivity in Clear Cell Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.04.009
Abstract: Advanced clear cell ovarian cancer (CCOC) is a highly fatal malignancy with a scarcity of effective treatment options. CCOC is inherently chemotherapy resistance, but the exact mechanism of this resistance has yet to be established.… read more here.
Keywords: urml 3881; inhibition; ovarian cancer; cancer ... See more keywords
Clear Cell Ovarian Cancer: Optimum Management and Prognosis Remain Hazy.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.10.012
Abstract: Epithelial ovarian cancer consists of several histological subtypes including low versus high grade serous, clear cell, endometrioid, and mucinous adenocarcinomas. These cell types have different patient demographics, carcinogenesis, molecular alterations, clinical presentations and prognoses [1].… read more here.
Keywords: ovarian cancer; cancer; oncology; clear cell ... See more keywords
A case report of small cell ovarian neuroendocrine carcinoma combined with immunochemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031445
Abstract: Background: Small cell ovarian neuroendocrine (NE) carcinoma is a rare NE tumor with a low incidence, poor prognosis, and no standardized treatment. To date, there have been no clear reports on the efficacy or prognosis… read more here.
Keywords: small cell; neuroendocrine carcinoma; ovarian neuroendocrine; cell ovarian ... See more keywords
Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-2674
Abstract: We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology indication may represent potential therapeutic targets. To test this hypothesis, we performed genome-scale… read more here.
Keywords: clear cell; cancer; egln1 dependency; cell ... See more keywords
Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-3817
Abstract: Abstract Purpose: To identify molecular subclasses of clear cell ovarian carcinoma (CCOC) and assess their impact on clinical presentation and outcomes. Experimental Design: We profiled 421 primary CCOCs that passed quality control using a targeted… read more here.
Keywords: molecular subclasses; cell ovarian; clear cell; ovarian carcinoma ... See more keywords
Abstract 1055: ORF1p expression from LINE-1 occurs in clear cell ovarian carcinoma precursors and is detectable in patients’ plasma samples
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1055
Abstract: Long interspersed element 1 (LINE-1) retrotransposons are repetitive genomic sequences able to move across the genome by an autonomous “copy and paste” mechanism. Given the mutagenic potential of LINE-1, benign cells restrict its expression, although… read more here.
Keywords: clear cell; cell ovarian; ovarian carcinoma; expression ... See more keywords
Abstract 4298: Investigating the potential of EO3001 as a therapeutic agent for clear cell ovarian cancers harboring ARID1A mutations
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4298
Abstract: Clear cell ovarian cancer (CCOC) is a histological subtype of ovarian cancer that is resistant to standard chemotherapies. Although it accounts for only around 6% of all ovarian cancer cases, it is the second leading… read more here.
Keywords: cancer; cell ovarian; cell; ccoc ... See more keywords
Abstract B055: Identifying compounds to promote apoptotic cell death in clear cell ovarian cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.ovarian23-b055
Abstract: Clear cell ovarian cancer is a rare subtype of ovarian cancer with a poor prognosis in advanced-stage disease and increased resistance to standard-of-care treatments including platinum chemotherapy. Previously, we found that multiple clear cell ovarian… read more here.
Keywords: cancer; cell lines; cell ovarian; cell ... See more keywords
The Tumor Microenvironment of Clear-Cell Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0407
Abstract: The tumor microenvironment (TME) of clear cell ovarian cancer is characterized. Immune infiltration and collagen deposition differ based on disease stage, TME localization, and ARID1A status, highlighting the necessity of evaluating multiple features when determining… read more here.
Keywords: ovarian cancer; cell ovarian; tumor microenvironment; clear cell ... See more keywords
Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Oncology"
DOI: 10.2139/ssrn.3377550
Abstract: Background Granulosa cell ovarian tumor (GCT) is characterized by a pathognomonic mutation in the FOXL2 gene (402 C > G) that leads to an overactivation of steroidogenesis. CYP17 is a key enzyme in such process and can… read more here.
Keywords: oncology; cell ovarian; trial; granulosa cell ... See more keywords
Tumor Immune Microenvironment and Checkpoint Inhibition in Clear Cell Ovarian Carcinoma: Bridging Tumor Biology and Clinical Application in Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb47090726
Abstract: Clear cell ovarian carcinoma is a rare and aggressive histologic subtype of epithelial ovarian cancer, characterized by a chemoresistant phenotype and distinct immunogenomic features. Despite early-phase trials showing a limited response to immune checkpoint inhibitors… read more here.
Keywords: biology; cell ovarian; tumor; ovarian carcinoma ... See more keywords