Live Cell Painting: image-based profiling in live cells using Acridine Orange.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e24-07-0308
Abstract: Image-based profiling has been used to analyze cell health, drug mechanism of action, CRISPR-edited cells, and overall cytotoxicity. Cell Painting is a broadly used image-based assay that uses morphological features to capture how cells respond… read more here.
Keywords: live cell; cell painting; image based; cell ... See more keywords
The Use of Cell Painting and Fluorescence Imaging to Assess Cell Physiological Responses to Glucose Stress
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.1746
Abstract: Cells of organisms encounter varying conditions, including daily and potentially seasonal fluctuations in available glucose. These fluctuations correspond primarily to feeding status and nutritional intake, with fed and fasted values ranging from ~4-7 mmol/L in… read more here.
Keywords: use cell; physiology; little brown; cell painting ... See more keywords
Abstract 4360792: Cell Painting Based High-Content Phenotypic Screening To Elucidate Kinase Signaling Pathways in BTK-Inhibitor Mediated Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4360792
Abstract: Introduction: One goal of Precision Cardio-Oncology is to identify and ultimately clinically exploit a fundamental understanding of shared signaling pathways in cardiovascular disease and oncologic processes, such as in BTK inhibitor-mediated atrial fibrillation. In clinical… read more here.
Keywords: cell painting; btk inhibitors; btk inhibitor; hipsc acms ... See more keywords
Phenotypic Profiling of Reference Chemicals across Biologically Diverse Cell Types Using the Cell Painting Assay
Sign Up to like & getrecommendations! Published in 2020 at "SLAS Discovery"
DOI: 10.1177/2472555220928004
Abstract: Cell Painting is a high-throughput phenotypic profiling assay that uses fluorescent cytochemistry to visualize a variety of organelles and high-content imaging to derive a large number of morphological features at the single-cell level. Most Cell… read more here.
Keywords: reference chemicals; phenotypic; painting assay; cell painting ... See more keywords
Systematic morphological profiling of human gene and allele function via Cell Painting
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.24060
Abstract: We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220 tested genes yielded detectable morphological… read more here.
Keywords: systematic morphological; cell painting; morphological profiling; function ... See more keywords