Antitumor activity of cell‐penetrant kinin B1 receptor antagonists in human triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27103
Abstract: High nuclear expression of G protein‐coupled receptors, including kinin B1 receptors (B1R), has been observed in several human cancers, but the clinical significance of this is unknown. We put forward the hypothesis that these “nuclearized”… read more here.
Keywords: breast cancer; cell penetrant; b1r; cell ... See more keywords
Dose-Dependent Nuclear Delivery and Transcriptional Repression with a Cell-Penetrant MeCP2
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01226
Abstract: Methyl-CpG-binding-protein 2 (MeCP2) is a nuclear protein expressed in all cell types, especially neurons1. Mutations in the MECP2 gene cause Rett syndrome (RTT), an incurable neurological disorder that disproportionately affects young girls2. Strategies to restore… read more here.
Keywords: cell; cell penetrant; nuclear delivery; mecp2 ... See more keywords
Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02603-2
Abstract: Lysine-selective molecular tweezers are promising drug candidates against proteinopathies, viral infection, and bacterial biofilm. Despite demonstration of their efficacy in multiple cellular and animal models, important questions regarding their mechanism of action, including cell penetrance… read more here.
Keywords: molecular tweezers; penetrant concentrate; tweezers cell; lysine selective ... See more keywords