Cell‐Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700095
Abstract: Many of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study, a cell‐penetrating peptide (CPP), VPTLK, derived from Ku70 protein, is employed to… read more here.
Keywords: peptide; cell; cell penetrating; protein aggregation ... See more keywords
Newly synthesized peptide, Ara‐27, exhibits significant improvement in cell‐penetrating ability compared to conventional peptides
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Progress"
DOI: 10.1002/btpr.3014
Abstract: Cell‐penetrating peptides (CPPs) are short amino acid sequences known to act as a vehicle for enhancing the intracellular translocating efficiency of extracellular molecules. Although many groups have attempted to develop peptides with high cell‐penetrating efficiencies,… read more here.
Keywords: ara; cell penetrating; significant improvement; cell ... See more keywords
Structure‐Based Design of a New Scaffold for Cell‐Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700109
Abstract: The histone demethylase PHF8 catalyzes demethylation of mono‐ and di‐methylated Lys9 on histone H3 (H3K9me1/2), and is a transcriptional activator involved in the development and cancer. Affinity and specificity of PHF8 towards H3K9me2 is affected… read more here.
Keywords: demethylase phf8; histone demethylase; structure based; cell penetrating ... See more keywords
A Conjugate of an Anti‐Epidermal Growth Factor Receptor (EGFR) VHH and a Cell‐Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700444
Abstract: Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors, and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell‐penetrating peptide (CPP),… read more here.
Keywords: conjugate; penetrating peptide; cell penetrating; activation ... See more keywords
Sidechain Engineering in Cell-Penetrating Poly(disulfide)s
Sign Up to like & getrecommendations! Published in 2017 at "Helvetica Chimica Acta"
DOI: 10.1002/hlca.201600370
Abstract: Cell-penetrating poly(disulfide)s (CPDs) have been introduced recently to explore new ways to enter into cells. In this report, we disclose a general method to covalently modify the sidechains of CPDs. Compatibility of copper-catalyzed alkyne-azide cycloaddition… read more here.
Keywords: disulfide; penetrating poly; cell penetrating; poly disulfide ... See more keywords
Intestinal barrier tightening by a cell‐penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27716
Abstract: Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon… read more here.
Keywords: barrier; antibody bin1; cell penetrating; ulcerative colitis ... See more keywords
Preparation and cellular uptake of bicyclic‐peptide cargo clicked to cell penetrating peptides
Sign Up to like & getrecommendations! Published in 2018 at "Peptide Science"
DOI: 10.1002/pep2.24037
Abstract: Cell penetrating peptides (CPPs) are frequently used to deliver peptide cargo into cells where they can exert their biological activity. Their success, however, can be dependent on the cargo, the cell type, and other variables… read more here.
Keywords: peptide; penetrating peptides; cell penetrating; peptide cargo ... See more keywords
Nα‐Methylation of arginine: Implications for cell‐penetrating peptides
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3468
Abstract: The field of cell‐penetrating peptides is dominated by the use of oligomers of arginine residues. Octanol–water partitioning in the presence of an anionic lipid is a validated proxy for cell‐penetrative efficacy. Here, we add one,… read more here.
Keywords: penetrating peptides; arginine implications; methylation arginine; cell penetrating ... See more keywords
Cell-Penetrating Peptides Delivering siRNAs: An Overview.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1298-9_18
Abstract: Cell-Penetrating Peptides (CPP) are valuable tools capable of crossing the plasma membrane to deliver therapeutic cargo inside cells. Small interfering RNAs (siRNA) are double-stranded RNA molecules capable of silencing the expression of a specific protein… read more here.
Keywords: peptides delivering; penetrating peptides; cell penetrating; overview ... See more keywords
Cell-Penetrating Peptides as Carriers for Transepithelial Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1752-6_24
Abstract: This chapter describes the use of cell-penetrating peptides (CPPs) as carriers for transepithelial delivery of therapeutic peptides. Assessment of transepithelial peptide permeation and the mechanisms of action that permeability enhancing drug carriers exert on the… read more here.
Keywords: penetrating peptides; delivery; drug; cell penetrating ... See more keywords
Artificial Evolutionary Optimization Process to Improve the Functionality of Cell Penetrating Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1752-6_3
Abstract: Crossing cellular membranes is a versatile molecular property that allows for a wide variety of peptides with cell penetrating capabilities. This broadness complicates identification of candidates suited best for a specific application. To facilitate the… read more here.
Keywords: penetrating peptides; artificial evolutionary; optimization process; cell penetrating ... See more keywords