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   Articles with "cell penetrating" as a keyword



Cell‐Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis

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recommendations! Published in 2018 at "Advanced Biosystems"

DOI: 10.1002/adbi.201700095

Abstract: Many of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study, a cell‐penetrating peptide (CPP), VPTLK, derived from Ku70 protein, is employed to… read more here.

Keywords: peptide; cell; cell penetrating; protein aggregation ... See more keywords

Engineered Streptococcus suis Bacterial Ghosts via Lytic Plasmid and Cell-Penetrating Peptides for Enhanced Protective Immunity.

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recommendations! Published in 2025 at "Advanced healthcare materials"

DOI: 10.1002/adhm.202503790

Abstract: Bacterial ghosts (BGs) prepared by biological methods effectively preserve their morphological and antigenic characteristics, making them excellent vaccine carriers for robust immune response. Streptococcus suis is a zoonotic pathogen that causes severe human infections such… read more here.

Keywords: streptococcus suis; immunity; cell penetrating; bacterial ghosts ... See more keywords

Newly synthesized peptide, Ara‐27, exhibits significant improvement in cell‐penetrating ability compared to conventional peptides

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recommendations! Published in 2020 at "Biotechnology Progress"

DOI: 10.1002/btpr.3014

Abstract: Cell‐penetrating peptides (CPPs) are short amino acid sequences known to act as a vehicle for enhancing the intracellular translocating efficiency of extracellular molecules. Although many groups have attempted to develop peptides with high cell‐penetrating efficiencies,… read more here.

Keywords: ara; cell penetrating; significant improvement; cell ... See more keywords

Structure‐Based Design of a New Scaffold for Cell‐Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700109

Abstract: The histone demethylase PHF8 catalyzes demethylation of mono‐ and di‐methylated Lys9 on histone H3 (H3K9me1/2), and is a transcriptional activator involved in the development and cancer. Affinity and specificity of PHF8 towards H3K9me2 is affected… read more here.

Keywords: demethylase phf8; histone demethylase; structure based; cell penetrating ... See more keywords

A Conjugate of an Anti‐Epidermal Growth Factor Receptor (EGFR) VHH and a Cell‐Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700444

Abstract: Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors, and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell‐penetrating peptide (CPP),… read more here.

Keywords: conjugate; penetrating peptide; cell penetrating; activation ... See more keywords

Efficient Synthesis of Cleavable Cell‐Penetrating Peptide–Cargo Conjugate via Low‐Equivalent of Cell‐Penetrating Peptide Activated by 2,2′‐Dithiodipyridine

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recommendations! Published in 2025 at "ChemBioChem"

DOI: 10.1002/cbic.202500032

Abstract: Cell‐penetrating peptides (CPPs) are favored for protein delivery due to their efficiency, rapidity, and low toxicity. However, conjugation of CPPs to proteins often requires significant amounts of CPPs to ensure yields, which also may result… read more here.

Keywords: cargo; synthesis cleavable; penetrating peptide; cell ... See more keywords

PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid

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recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500242

Abstract: Folic acid is an essential component of many metabolic processes, including the synthesis of nucleoproteins, purines, and pyrimidines, and is a recommended supplement to lower the incidence of various disorders. Folic acid and folate‐loaded nanoparticles… read more here.

Keywords: folic acid; penetrating peptide; cellular uptake; acid ... See more keywords

Sidechain Engineering in Cell-Penetrating Poly(disulfide)s

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recommendations! Published in 2017 at "Helvetica Chimica Acta"

DOI: 10.1002/hlca.201600370

Abstract: Cell-penetrating poly(disulfide)s (CPDs) have been introduced recently to explore new ways to enter into cells. In this report, we disclose a general method to covalently modify the sidechains of CPDs. Compatibility of copper-catalyzed alkyne-azide cycloaddition… read more here.

Keywords: disulfide; penetrating poly; cell penetrating; poly disulfide ... See more keywords

Intestinal barrier tightening by a cell‐penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis

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recommendations! Published in 2019 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27716

Abstract: Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon… read more here.

Keywords: barrier; antibody bin1; cell penetrating; ulcerative colitis ... See more keywords

Preparation and cellular uptake of bicyclic‐peptide cargo clicked to cell penetrating peptides

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recommendations! Published in 2018 at "Peptide Science"

DOI: 10.1002/pep2.24037

Abstract: Cell penetrating peptides (CPPs) are frequently used to deliver peptide cargo into cells where they can exert their biological activity. Their success, however, can be dependent on the cargo, the cell type, and other variables… read more here.

Keywords: peptide; penetrating peptides; cell penetrating; peptide cargo ... See more keywords

Nα‐Methylation of arginine: Implications for cell‐penetrating peptides

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recommendations! Published in 2022 at "Journal of Peptide Science"

DOI: 10.1002/psc.3468

Abstract: The field of cell‐penetrating peptides is dominated by the use of oligomers of arginine residues. Octanol–water partitioning in the presence of an anionic lipid is a validated proxy for cell‐penetrative efficacy. Here, we add one,… read more here.

Keywords: penetrating peptides; arginine implications; methylation arginine; cell penetrating ... See more keywords