Phagosomes of Different Size Show Qualitatively Different Transport Characteristics
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1474
Abstract: As one of the key processes during the immune response, phagocytosis of bacteria plays a significant role in the mammalian immune system. A crucial part of phagocytosis is the transport of phagosomes from the cell… read more here.
Keywords: perinuclear region; phagosome size; transport characteristics; transport ... See more keywords
p150glued deficiency impairs effective fusion between autophagosomes and lysosomes due to their redistribution to the cell periphery
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.036
Abstract: Dynein-dynactin has an indispensable role in autophagy and p150glued is the largest component of the dynactin complex. Here, we characterized the effects of knockdown (KD) of endogenous p150glued and of the pathogenic mutation of p150glued… read more here.
Keywords: autophagosomes lysosomes; p150glued deficiency; periphery p150glued; fusion ... See more keywords
PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-07-0355
Abstract: Copper homeostasis is crucial for cellular physiology and development, and its dysregulation leads to disease. The Menkes ATPase ATP7A plays a key role in copper efflux, by trafficking from the Golgi to the plasma membrane… read more here.
Keywords: atp7a cell; cell periphery; plekha5 plekha6; copper ... See more keywords