A whole-cell pertussis vaccine engineered to elicit reduced reactogenicity protects baboons against pertussis challenge
Sign Up to like & getrecommendations! Published in 2024 at "mSphere"
DOI: 10.1128/msphere.00647-24
Abstract: ABSTRACT Whole-cell pertussis (wP) vaccines introduced in the 1940s led to a dramatic reduction of pertussis incidence and are still widely used in low- and middle-income countries (LMICs) worldwide. The reactogenicity of wP vaccines resulted… read more here.
Keywords: pertussis; whole cell; cell pertussis; immunization ... See more keywords
Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters
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DOI: 10.1172/jci121309
Abstract: In the mid-1990s, whole-cell pertussis (wP) vaccines were associated with local and systemic adverse events that prompted their replacement with acellular pertussis (aP) vaccines in many high-income countries. In the past decade, rates of pertussis… read more here.
Keywords: whole cell; polarization; th1 th17; cell pertussis ... See more keywords