Morphogen regulation of stem cell plasticity in intestinal regeneration and carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.434
Abstract: The intestinal epithelium is a tissue with high cell turnover, supported by adult intestinal stem cells. Intestinal homeostasis is underpinned by crypt basal columnar stem cells, marked by expression of the LGR5 gene. However, recent… read more here.
Keywords: cell plasticity; stem; cell; stem cell ... See more keywords
A cellular and molecular view of T helper 17 cell plasticity in autoimmunity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.12.007
Abstract: Since the original identification of the T helper 17 (Th17) subset in 2005, it has become evident that these cells do not only contribute to host defence against pathogens, such as bacteria and fungi, but… read more here.
Keywords: cell plasticity; th17 cells; cellular molecular; autoimmunity ... See more keywords
On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.11.010
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating type of cancer. While many studies have shed light into the pathobiology of PDAC, the nature of PDAC’s cell of origin remains under debate. Studies in adult pancreatic… read more here.
Keywords: cancer; exocrine cell; tumor subtypes; cell plasticity ... See more keywords
Cell plasticity in cancer: A complex interplay of genetic, epigenetic mechanisms and tumor micro-environment.
Sign Up to like & getrecommendations! Published in 2020 at "Surgical oncology"
DOI: 10.1016/j.suronc.2020.04.017
Abstract: Cell plasticity, also known as lineage plasticity is defined as the ability of a cell to reprogram and change its phenotype identity. Cell plasticity is context dependent and occurs during the development of an embryo,… read more here.
Keywords: cell plasticity; plasticity cancer; complex interplay; cell ... See more keywords
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87292-x
Abstract: When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in programming… read more here.
Keywords: igf2 programmes; autocrine igf2; cell plasticity; autocrine ... See more keywords
Understanding cancer cell plasticity: EMT, respecialisation, and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Molecular Medicine"
DOI: 10.1038/s44321-025-00288-2
Abstract: The epithelial–mesenchymal transition (EMT) is a source of cancer cell plasticity and tumour heterogeneity, and is increasingly recognised as a complex and dynamic process (Aiello et al, 2018; Brown et al, 2022). EMT should not… read more here.
Keywords: cancer; understanding cancer; cell plasticity; plasticity ... See more keywords
Dysplastic stem cell plasticity functions as a driving force for neoplastic transformation of pre-cancerous gastric mucosa.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.06.021
Abstract: BACKGROUND & AIMS Dysplasia carries a high risk of cancer development, however, the cellular mechanisms for dysplasia evolution to cancer are obscure. We have previously identified two putative dysplastic stem cell (DSC) populations, CD44v6neg/CD133+/CD166+ (DP)… read more here.
Keywords: cell; cell plasticity; dysplastic stem; stem cell ... See more keywords
Melanoma cell plasticity poses diagnostic challenges: a case series.
Sign Up to like & getrecommendations! Published in 2022 at "Melanoma research"
DOI: 10.1097/cmr.0000000000000852
Abstract: Phenotype switching is an emerging concept in melanoma research and deals with the cancer cell plasticity. In this paper, we present five cases of patients with metastatic malignant melanoma where the tumor underwent dramatic morphological… read more here.
Keywords: plasticity poses; melanoma cell; cell plasticity; melanoma ... See more keywords
Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002758
Abstract: Supplemental Digital Content is Available in the Text. Deep learning-based analysis of large-scale bioimages of the dorsal root ganglion after nerve injury reveals satellite glial cell plasticity but no loss of sensory neurons. read more here.
Keywords: cell plasticity; satellite glial; root ganglion; nerve injury ... See more keywords
Abstract 5793: Met confers radioresistance-associated aggressiveness through enhancing PLXDC2-mediated cancer stem cell plasticity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5793
Abstract: The development of radioresistance in head and neck squamous cell carcinoma (HNSCC) remains a significant problem in cancer treatment, contributing to the lack of improvement in survival trends in the past decades. One of the… read more here.
Keywords: cell plasticity; stem cell; cancer stem; radioresistance associated ... See more keywords
Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms
Sign Up to like & getrecommendations! Published in 2019 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.118.311727
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: vascular smooth; cell plasticity; muscle cell; autophagy dissecting ... See more keywords