Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes
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DOI: 10.1002/ijc.32503
Abstract: Viruses can inhibit host autophagy through multiple mechanisms, and evasion of autophagy plays an important role in immune suppression and viral oncogenesis. Merkel cell polyomavirus (MCPyV) T‐antigens are expressed and involved in the pathogenesis of… read more here.
Keywords: cell polyomavirus; autophagy; merkel cell; mcpyv ... See more keywords
Exploring the effects of Merkel cell polyomavirus T antigens expression in REH and MCC13 cells by methylome and transcriptome profiling
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29938
Abstract: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with a tripled incidence in the US and Europe over the past decade. Around 80% of MCC is linked to Merkel cell polyomavirus, but the… read more here.
Keywords: reh; cell polyomavirus; cell; merkel cell ... See more keywords
Molecular detection of Merkel cell polyomavirus in basal cell carcinoma and perilesional tissue: a cross-sectional study☆☆☆
Sign Up to like & getrecommendations! Published in 2020 at "Anais Brasileiros de Dermatologia"
DOI: 10.1016/j.abd.2019.10.007
Abstract: The first and so far only oncogenic human polyomavirus, Merkel cell polyomavirus (MCPyV), was discovered in the last decade, infecting about 80% of Merkel cell carcinomas (MCC) and 40% of healthy individuals. Originated from cells… read more here.
Keywords: merkel cell; basal cell; cell; cell polyomavirus ... See more keywords
Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.277
Abstract: The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often… read more here.
Keywords: merkel; merkel cell; ligase targeting; cell polyomavirus ... See more keywords
Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors
Sign Up to like & getrecommendations! Published in 2019 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.12953
Abstract: The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using diverse molecular techniques, we reported the presence of human polyomavirus 7 (HPyV7) in… read more here.
Keywords: merkel cell; prevalence merkel; cell polyomavirus; polyomavirus ... See more keywords
Merkel cell polyomavirus is uncommon in New Zealand Merkel cell carcinomas
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Dermatology"
DOI: 10.1111/bjd.16903
Abstract: Merkel Cell Carcinoma (MCC) is a rare skin tumour with an incidence of 0.88 per 100,000 people in New Zealand (NZ), one of the highest in the world1 and almost on par with close neighbours… read more here.
Keywords: new zealand; cell polyomavirus; polyomavirus uncommon; merkel ... See more keywords
Molecular prevalence of Merkel cell polyomavirus in nonmelanoma skin cancer in a Brazilian population
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13069
Abstract: Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on… read more here.
Keywords: merkel cell; molecular prevalence; cell; cell polyomavirus ... See more keywords
Immunological evidence of an early seroconversion to oncogenic Merkel cell polyomavirus in healthy children and young adults
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13601
Abstract: Oncogenic Merkel cell polyomavirus (MCPyV) provokes a widespread and asymptomatic infection in humans. Herein, sera from healthy children and young adults (HC, n = 344) aged 0–20 years old were evaluated for anti‐MCPyV immunoglobulin G (IgG)… read more here.
Keywords: oncogenic merkel; merkel cell; mcpyv; cell polyomavirus ... See more keywords
Characterization of the Impact of Merkel Cell Polyomavirus-Induced Interferon Signaling on Viral Infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01907-22
Abstract: Merkel cell carcinoma is an aggressive skin cancer that is particularly lethal to immunocompromised individuals. Though rare, MCC incidence has increased significantly in recent years. ABSTRACT Merkel cell polyomavirus (MCPyV) has been associated with approximately… read more here.
Keywords: cell polyomavirus; infection; mcpyv infection; merkel cell ... See more keywords
Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation
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DOI: 10.1128/mbio.01117-24
Abstract: ABSTRACT Merkel cell polyomavirus (MCPyV) is a double-stranded tumor virus that is the main causative agent of Merkel cell carcinoma (MCC). The MCPyV large T antigen (LT), an essential viral DNA replication protein, maintains viral… read more here.
Keywords: replication; cell polyomavirus; cell; merkel cell ... See more keywords
Molecular Mechanisms of Merkel Cell Polyomavirus Transformation and Replication.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of virology"
DOI: 10.1146/annurev-virology-011720-121757
Abstract: Viral infection underlies a significant share of the global cancer burden. Merkel cell polyomavirus (MCPyV) is the newest member of the human oncogenic virus family. Its discovery over a decade ago marked the beginning of… read more here.
Keywords: merkel cell; mcpyv; virology; cell polyomavirus ... See more keywords