Generation of High Expressing Chinese Hamster Ovary Cell Pools Using the Leap-In Transposon System.
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DOI: 10.1002/biot.201700748
Abstract: Clonally derived cell lines (CDCL) from Chinese Hamster Ovary (CHO) host cell lines, remain the most popular method to manufacture therapeutic proteins. However, CHO cell pools are increasingly being used as an alternate method to… read more here.
Keywords: cell pools; hamster ovary; chinese hamster; generation high ... See more keywords
Accelerating HIV‐1 VLP production using stable High Five insect cell pools
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DOI: 10.1002/biot.202000391
Abstract: Stable cell pools are receiving a renewed interest as a potential alternative system to clonal cell lines. The shorter development timelines and the capacity to achieve high product yields make them an interesting approach for… read more here.
Keywords: cell pools; high five; production; stable high ... See more keywords
Development of an efficient method for selection of stable cell pools for protein expression and surface display with Expi293F cells
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DOI: 10.1002/cbf.3787
Abstract: Compare with transient expression, stable cell lines generally have higher productivity and better quality for protein expression. However, selection of stable cell line is time‐consuming and laborious. Here we describe an optimized selection method to… read more here.
Keywords: cell; cell pools; expression; method ... See more keywords
Shortening the Biologics Clinical Timeline with a Novel Method for Generating Stable, High Producing Cell Pools and Clones.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.22541/au.167113298.81559773/v1
Abstract: Reducing drug development timelines is an industry-wide goal to bring medicines to patients in need more quickly. This was exemplified in the COVID-19 pandemic where reducing development timelines had a direct impact on the number… read more here.
Keywords: development timelines; cell pools; pools clones; biologics clinical ... See more keywords
A platform for automated and label-free monitoring of morphological features and kinetics of spheroid fusion
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DOI: 10.3389/fbioe.2022.946992
Abstract: Spheroids are widely applied as building blocks for biofabrication of living tissues, where they exhibit spontaneous fusion toward an integrated structure upon contact. Tissue fusion is a fundamental biological process, but due to a lack… read more here.
Keywords: spheroid fusion; platform; fusion; cell pools ... See more keywords