A dormant T‐cell population with autoimmune potential exhibits low self‐reactivity and infiltrates islets in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149690
Abstract: The contribution of low‐affinity T cells to autoimmunity in the context of polyclonal T‐cell responses is understudied due to the limitations in their capture by tetrameric reagents and low level of activation in response to… read more here.
Keywords: cell; affinity; reactivity; effector ... See more keywords
Integrating Cell Population Data With Hematology Analyzer Messages for Improved Detection of Immature White Blood Cells and Laboratory Efficiency
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.70099
Abstract: Improving efficiency and reducing turnaround time are crucial in clinical laboratories. While automated analyzers such as the Beckman Coulter DxH 900 streamline workflow, subtle abnormalities like blasts and immature granulocytes (IGs) may be missed, especially… read more here.
Keywords: integrating cell; efficiency; population data; cell population ... See more keywords
Microfluidic Platform for Parallel Single Cell Analysis for Diagnostic Applications.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6734-6_15
Abstract: Cell populations are heterogeneous: they can comprise different cell types or even cells at different stages of the cell cycle and/or of biological processes. Furthermore, molecular processes taking place in cells are stochastic in nature.… read more here.
Keywords: single cell; analysis; cell population; diagnostic applications ... See more keywords
Single Cell and Population Level Analysis of HCA Data.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7357-6_15
Abstract: High Content Analysis instrumentation has undergone tremendous hardware advances in recent years. It is now possible to obtain images of hundreds of thousands to millions of individual objects, across multiple wells, channels, and plates, in… read more here.
Keywords: single cell; analysis hca; population level; level analysis ... See more keywords
Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107872
Abstract: SUMMARY The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus obstruction of the airways. To further investigate this incompletely understood pathobiology, we characterize IL-13 effects on human airway epithelial cell cultures using… read more here.
Keywords: single cell; population transcriptomics; cell population; high asthma ... See more keywords
Molecular noise can minimize the collective sensitivity of a clonal heterogeneous cell population.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2016.12.023
Abstract: It is now widely accepted that molecular noise, rather than be always detrimental, introduces in many circumstances the required boost to reach fundamental cellular activities or strategies otherwise unattainable. In threshold-like genetic systems, molecular noise… read more here.
Keywords: noise minimize; molecular noise; cell population; noise ... See more keywords
Cytometry of Reaction Rate Constant: Measuring Reaction Rate Constant in Individual Cells To Facilitate Robust and Accurate Analysis of Cell-Population Heterogeneity.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b00388
Abstract: Robust and accurate analysis of cell-population heterogeneity is challenging but required in many areas of biology and medicine. In particular, it is pivotal to the development of reliable cancer biomarkers. Here, we prove that cytometry… read more here.
Keywords: heterogeneity; cell population; reaction rate; reaction ... See more keywords
Inference of differentiation time for single cell transcriptomes using cell population reference data
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01860-2
Abstract: Single-cell RNA sequencing (scRNA-seq) is a powerful method for dissecting intercellular heterogeneity during development. Conventional trajectory analysis provides only a pseudotime of development, and often discards cell-cycle events as confounding factors. Here using matched cell… read more here.
Keywords: single cell; seq; cell population; differentiation ... See more keywords
A vasculature-resident innate lymphoid cell population in mouse lungs
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58982-1
Abstract: Tissue-resident immune cells such as innate lymphoid cells (ILC) are known to reside in the parenchymal compartments of tissues and modulate local immune protection. Here we use intravascular cell labeling, parabiosis and multiplex 3D imaging… read more here.
Keywords: cell population; population; mouse; innate lymphoid ... See more keywords
A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62709-7
Abstract: Reports of secondary malignancies after chimeric antigen receptor (CAR)-T and possible CAR-T derived malignant transformation necessitate caution. Here we describe a patient with diffuse large B-cell lymphoma who developed new lymphadenopathy 2.5 years after CAR-T… read more here.
Keywords: cell lymphoma; cell population; car therapy; car ... See more keywords
Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-37686-1
Abstract: Stem cell-derived cardiomyocytes and vascular cells can be used for a variety of applications such as studying human heart development and modelling human disease in culture. In particular, protocols based on modulation of Wnt signaling… read more here.
Keywords: cardiovascular spheroids; cell population; pluripotent stem; yap ... See more keywords