A dormant T‐cell population with autoimmune potential exhibits low self‐reactivity and infiltrates islets in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149690
Abstract: The contribution of low‐affinity T cells to autoimmunity in the context of polyclonal T‐cell responses is understudied due to the limitations in their capture by tetrameric reagents and low level of activation in response to… read more here.
Keywords: cell; affinity; reactivity; effector ... See more keywords
Microfluidic Platform for Parallel Single Cell Analysis for Diagnostic Applications.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6734-6_15
Abstract: Cell populations are heterogeneous: they can comprise different cell types or even cells at different stages of the cell cycle and/or of biological processes. Furthermore, molecular processes taking place in cells are stochastic in nature.… read more here.
Keywords: single cell; analysis; cell population; diagnostic applications ... See more keywords
Single Cell and Population Level Analysis of HCA Data.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7357-6_15
Abstract: High Content Analysis instrumentation has undergone tremendous hardware advances in recent years. It is now possible to obtain images of hundreds of thousands to millions of individual objects, across multiple wells, channels, and plates, in… read more here.
Keywords: single cell; analysis hca; population level; level analysis ... See more keywords
Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107872
Abstract: SUMMARY The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus obstruction of the airways. To further investigate this incompletely understood pathobiology, we characterize IL-13 effects on human airway epithelial cell cultures using… read more here.
Keywords: single cell; population transcriptomics; cell population; high asthma ... See more keywords
Molecular noise can minimize the collective sensitivity of a clonal heterogeneous cell population.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2016.12.023
Abstract: It is now widely accepted that molecular noise, rather than be always detrimental, introduces in many circumstances the required boost to reach fundamental cellular activities or strategies otherwise unattainable. In threshold-like genetic systems, molecular noise… read more here.
Keywords: noise minimize; molecular noise; cell population; noise ... See more keywords
Cytometry of Reaction Rate Constant: Measuring Reaction Rate Constant in Individual Cells To Facilitate Robust and Accurate Analysis of Cell-Population Heterogeneity.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b00388
Abstract: Robust and accurate analysis of cell-population heterogeneity is challenging but required in many areas of biology and medicine. In particular, it is pivotal to the development of reliable cancer biomarkers. Here, we prove that cytometry… read more here.
Keywords: heterogeneity; cell population; reaction rate; reaction ... See more keywords
Inference of differentiation time for single cell transcriptomes using cell population reference data
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01860-2
Abstract: Single-cell RNA sequencing (scRNA-seq) is a powerful method for dissecting intercellular heterogeneity during development. Conventional trajectory analysis provides only a pseudotime of development, and often discards cell-cycle events as confounding factors. Here using matched cell… read more here.
Keywords: single cell; seq; cell population; differentiation ... See more keywords
Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-37686-1
Abstract: Stem cell-derived cardiomyocytes and vascular cells can be used for a variety of applications such as studying human heart development and modelling human disease in culture. In particular, protocols based on modulation of Wnt signaling… read more here.
Keywords: cardiovascular spheroids; cell population; pluripotent stem; yap ... See more keywords
Effect of reward on electrophysiological signatures of grid cell population activity in human spatial navigation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-03124-y
Abstract: The regular equilateral triangular periodic firing pattern of grid cells in the entorhinal cortex is considered a regular metric for the spatial world, and the grid-like representation correlates with hexadirectional modulation of theta (4–8 Hz)… read more here.
Keywords: cell population; navigation; grid cell; population activity ... See more keywords
Stem Cells in the Periodontium—Anatomically Related Yet Physiologically Diverse
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Dentistry"
DOI: 10.1055/s-0042-1759487
Abstract: Abstract Periodontitis is a complex chronic disease discernible by the deterioration of periodontal tissue. The goal of periodontal therapy is to achieve complete tissue regeneration, and one of the most promising treatment options is to… read more here.
Keywords: stem cell; cell population; stem; stem cells ... See more keywords
Effects of Subcutaneous Repository Corticotropin Gel Injection on Regulatory T Cell Population in Noninfectious Retinal Vasculitis
Sign Up to like & getrecommendations! Published in 2022 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2022.2042323
Abstract: ABSTRACT Aim To evaluate the effect of repository corticotropin injection (RCI) on regulatory T cell population in patients with noninfectious retinal vasculitis. Patients and Methods Patients with active noninfectious retinal vasculitis were included in a… read more here.
Keywords: vasculitis; regulatory cell; retinal vasculitis; cell population ... See more keywords