Blinatumomab as first salvage versus second or later salvage in adults with relapsed/refractory B‐cell precursor acute lymphoblastic leukemia: Results of a pooled analysis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3731
Abstract: Blinatumomab is a BiTE® immuno‐oncology therapy indicated for the treatment of patients with relapsed or refractory (r/r) B‐cell precursor (BCP) acute lymphoblastic leukemia (ALL). read more here.
Keywords: relapsed refractory; lymphoblastic leukemia; blinatumomab; cell precursor ... See more keywords
Integrated clinical genotype‐phenotype characteristics of early T‐cell precursor acute lymphoblastic leukemia
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DOI: 10.1002/cncr.34515
Abstract: Early T‐cell precursor acute lymphoblastic leukemia (ETP‐ALL) is a distinct subtype of T‐ALL with a unique immunophenotype and high treatment failure rate. The molecular genetic abnormalities and their prognostic impact in ETP‐ALL patients are poorly… read more here.
Keywords: cell precursor; precursor acute; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Prognostic significance of IKZF1 deletions and IKZF1plus profile in children with B-cell precursor acute lymphoblastic leukemia treated according to the ALL-IC BFM 2009 protocol.
Sign Up to like & getrecommendations! Published in 2022 at "Hematological oncology"
DOI: 10.1002/hon.2973
Abstract: The strongest predictors of outcome in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are minimal residual disease (MRD) and specific molecular abnormalities. One unfavorable prognostic factor is the presence of IKZF1 gene aberrations, particularly when… read more here.
Keywords: precursor acute; protocol; treated according; cell precursor ... See more keywords
Clinician Concepts of Cure in Adult Relapsed and Refractory Philadelphia-Negative B Cell Precursor Acute Lymphoblastic Leukemia: A Delphi Study
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Therapy"
DOI: 10.1007/s12325-019-00910-z
Abstract: IntroductionDespite the poor prognosis for adults with relapsed or refractory (RR) Philadelphia chromosome (Ph)-negative B cell precursor acute lymphoblastic leukemia (ALL), long-term survival is possible and may even be considered as “cure”.MethodsThis study used a Delphi… read more here.
Keywords: relapsed refractory; leukemia; negative cell; cell precursor ... See more keywords
Benefit–Risk Assessment of Blinatumomab in the Treatment of Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Drug Safety"
DOI: 10.1007/s40264-018-0760-1
Abstract: Blinatumomab is the first-and-only Food and Drug Administration (FDA)-approved cluster of differentiation (CD) 19-directed CD3 bispecific T-cell engager (BiTE®) immunotherapy. It is currently FDA approved for the treatment of adults and children with Philadelphia chromosome-positive… read more here.
Keywords: relapsed refractory; blinatumomab treatment; cell precursor; refractory cell ... See more keywords
Efficacy of third-party chimeric antigen receptor modified peripheral blood natural killer cells for adoptive cell therapy of B-cell precursor acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0613-7
Abstract: We developed an innovative and efficient, feeder-free culture method to genetically modify and expand peripheral blood-derived NK cells with high proliferative capacity, while preserving the responsiveness of their native activating receptors. Activated peripheral blood NK… read more here.
Keywords: cell precursor; peripheral blood; therapy; cell ... See more keywords
Allogeneic HCT for adults with B-cell precursor acute lymphoblastic leukemia harboring IKZF1 gene mutations. A study by the Acute Leukemia Working Party of the EBMT
Sign Up to like & getrecommendations! Published in 2020 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-020-01139-z
Abstract: The presence of IKZF1 gene mutations is associated with poor prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The goal of this retrospective study was to evaluate outcome of allogeneic hematopoietic cell transplantation (allo-HCT) in… read more here.
Keywords: gene mutations; precursor acute; ikzf1 gene; cell precursor ... See more keywords
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia
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DOI: 10.1038/s41467-022-28218-7
Abstract: Kinase signaling fuels growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet its role in leukemia initiation is unclear and has not been shown in primary human hematopoietic cells. We previously described activating mutations in… read more here.
Keywords: primary human; bcp; cell precursor; role ... See more keywords
Role of Cytogenetics and FISH in Laboratory Workup of B Cell Precursor Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Indian Journal of Medical and Paediatric Oncology"
DOI: 10.1055/s-0043-1766133
Abstract: Abstract Modern therapeutic protocols in acute leukemias risk stratify disease based on genetic characterization of the neoplastic cells and their response to treatment. Genetic characterization is routinely performed by cytogenetic testing of leukemic cells and… read more here.
Keywords: cell precursor; lymphoblastic leukemia; risk; strategy ... See more keywords
Perspectives of Fc engineered antibodies in CD19 targeting immunotherapies in pediatric B-cell precursor acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1448331
Abstract: ABSTRACT CD19 immunotherapies based on T cells opened new avenues in the treatment of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, Fc engineered CD19 antibodies may also bear great potential. In light of recent… read more here.
Keywords: precursor acute; lymphoblastic leukemia; cell precursor; acute lymphoblastic ... See more keywords
Clinical and molecular characterization of early T-cell precursor acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000013856
Abstract: Rationale: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a small subtype of T-cell acute lymphoblastic leukemia with a typical immune-phenotype: lack of T-lineage cell surface markers CD1a and CD8 expression, weak or absent CD5… read more here.
Keywords: early cell; lymphoblastic leukemia; cell precursor; acute lymphoblastic ... See more keywords