Spreading the load: Antigen transfer between migratory and lymph node‐resident dendritic cells promotes T‐cell priming
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747248
Abstract: Dendritic cells (DC) are specialized in the processing and presentation of antigen for the activation of lymphocytes. Multiple subsets of DCs exist with distinct functions and roles in the initiation of immune responses. DCs found… read more here.
Keywords: dcs; lymph; dendritic cells; antigen ... See more keywords
Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93113-y
Abstract: Anti-PD-L1 antibodies benefit many cancer patients, even those with “non-inflamed tumor”. Determining which patients will benefit remains an important clinical goal. In a non-inflamed tumor mouse model, we found that PD-L1 was highly expressed on… read more here.
Keywords: cxcr3; response; atezolizumab; cell priming ... See more keywords
Immune checkpoint blockade lowers the threshold of naïve T-cell priming to drug-associated antigens in a dose-dependent fashion
Sign Up to like & getrecommendations! Published in 2024 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfae118
Abstract: Abstract A growing body of clinical and experimental evidence indicates that immune checkpoint blockade enhances patient susceptibility to hypersensitivity reactions to co-administered medications. In this study, we utilized an in vitro T-cell priming assay to… read more here.
Keywords: immune checkpoint; checkpoint blockade; cell; associated antigens ... See more keywords
Chlamydia trachomatis impairs T cell priming by inducing dendritic cell death
Sign Up to like & getrecommendations! Published in 2025 at "Infection and Immunity"
DOI: 10.1128/iai.00402-24
Abstract: ABSTRACT The lack of effective adaptive immunity against Chlamydia trachomatis leads to chronic or repeated infection and serious disease sequelae. Dendritic cells (DCs) are professional antigen-presenting cells that are crucial for the activation of T… read more here.
Keywords: chlamydia trachomatis; trachomatis; cell priming; cell death ... See more keywords
The tumor-targeted CD40 agonist CEA-CD40 promotes T cell priming via a dual mode of action by increasing antigen delivery to dendritic cells and enhancing their activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003264
Abstract: Tumor-targeted CD40 agonism represents an attractive strategy for cancer immunotherapy (CIT) as it promotes dendritic cell (DC) activation and concomitant tumor-specific T cell priming without causing systemic side effects. We developed the bispecific CD40 agonistic… read more here.
Keywords: cea cd40; cell priming; cea; tumor ... See more keywords
Decoy Receptor 3 Suppresses T-Cell Priming and Promotes Apoptosis of Effector T-Cells in Acute Cell-Mediated Rejection: The Role of Reverse Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.879648
Abstract: Background Decoy receptor 3 (DcR3) belongs to the tumor necrosis factor (TNF) receptor superfamily and neutralizes TNF ligands, including FasL and TRAIL, to prevent T activation during T-cell priming. However, the cellular mechanisms underlying acute… read more here.
Keywords: cell; dcr3; acute cell; cell priming ... See more keywords
Balancing Immunity: GSK-3’s Divergent Roles in Dendritic Cell-Mediated T-Cell Priming and Memory Responses
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26136078
Abstract: Glycogen synthase kinase-3 (GSK-3)—particularly the GSK-3β isoform—plays a pivotal role in regulating dendritic cell (DC) functions, including maturation, cytokine production, and antigen presentation. In immature DCs, GSK-3β is continuously active, and its inhibition has been… read more here.
Keywords: dendritic cell; cell; gsk; cell priming ... See more keywords