Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues
Sign Up to like & getrecommendations! Published in 2019 at "Engineering"
DOI: 10.1016/j.eng.2018.12.003
Abstract: Abstract Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can… read more here.
Keywords: cell products; quality control; cell; research ... See more keywords
Lessons Learned from Pioneering Neural Stem Cell Studies
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DOI: 10.1016/j.stemcr.2017.01.024
Abstract: As stem cell products are increasingly entering early stage clinical trials, we are learning from experience about how cell products may be best assessed for safety and efficacy. In two papers published in this issue… read more here.
Keywords: cell products; stem cell; lessons learned; cell ... See more keywords
293 Resultsof the first-in-human clinical trial with personalized multi-target adoptive cell therapy (ACTolog IMA101)
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0293
Abstract: Background ACTolog (IMA101) is a personalized multi-target adoptive cell therapy (ACT) approach in which autologous T-cell products are redirected against multiple novel defined peptide-HLA (pHLA) cancer targets identified by the target discovery platform XPRESIDENT®. The… read more here.
Keywords: tumor; cell products; target; actolog ... See more keywords
Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.896242
Abstract: Cellular immunotherapies based on T cell receptor (TCR) transfer are promising approaches for the treatment of cancer and chronic viral infections. The discovery of novel receptors is expanding considerably; however, the clinical development of TCR-T… read more here.
Keywords: tcr cell; scale manufacturing; cell; tcr ... See more keywords
Antiviral Cell Products against COVID-19: Learning Lessons from Previous Research in Anti-Infective Cell-Based Agents
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DOI: 10.3390/biomedicines10040868
Abstract: COVID-19 is a real challenge for the protective immunity. Some people do not respond to vaccination by acquiring an appropriate immunological memory. The risk groups for this particular infection such as the elderly and people… read more here.
Keywords: car lymphocytes; cell products; cell; sars cov ... See more keywords