Nanoliter-Scale Oil-Air-Droplet Chip-Based Single Cell Proteomic Analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b00661
Abstract: Single cell proteomic analysis provides crucial information on cellular heterogeneity in biological systems. Herein, we describe a nanoliter-scale oil-air-droplet (OAD) chip for achieving multistep complex sample pretreatment and injection for single cell proteomic analysis in… read more here.
Keywords: single cell; droplet; analysis; proteomic analysis ... See more keywords
Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-3183
Abstract: Single-cell proteomic profiling of clinical samples may facilitate the optimal selection of novel drug targets, interpretation of early-phase clinical trial data, and development of predictive biomarkers valuable for patient stratification. Cytometry by time-of-flight (CyTOF) simultaneously… read more here.
Keywords: proteomic profiling; cancer; cell; single cell ... See more keywords
Abstract B069: Spatial and single-cell proteomic landscaping of the hypoxic microenvironment in glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.liqbiop24-b069
Abstract: Glioblastoma (GBM) is a fatal adult solid tumour with median overall survival of 18-20 months post-diagnosis; contributing factors to therapeutic inefficacy include acquisition of genomic alterations post-therapy, immune evasion, deregulated hypervascularization, and tumor microenvironmental factors… read more here.
Keywords: hypoxic microenvironment; single cell; spatial single; cell proteomic ... See more keywords