MAP(K)ing the Path to Stem Cell Quiescence and the Elusive Enteroendocrine Cell.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.01.005
Abstract: The existence and interaction of proliferating and quiescent intestinal stem cells have been debated since their discovery in the 1970s. In this issue of Cell Stem Cell, using murine intestinal organoids, Basak et al. (2017) induce… read more here.
Keywords: enteroendocrine; stem cell; cell quiescence; stem ... See more keywords
Tis11 mediated mRNA decay promotes the reacquisition of Drosophila intestinal stem cell quiescence.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.04.013
Abstract: Adult stem cell proliferation rates are precisely regulated to maintain long-term tissue homeostasis. Defects in the mechanisms controlling stem cell proliferation result in impaired regeneration and hyperproliferative diseases. Many stem cell populations increase proliferation in… read more here.
Keywords: stem cell; proliferation rates; cell quiescence; proliferation ... See more keywords
mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aax0194
Abstract: Deadenylate or activate? When cells are quiescent, they undergo reversible cell cycle arrest and evince low basal metabolism. Naïve T cells are normally quiescent until they recognize cognate antigens through T cell receptor–costimulatory molecule signaling.… read more here.
Keywords: quiescence; btg1 btg2; cell quiescence;
The CD8α–PILRα interaction maintains CD8+ T cell quiescence
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.aaz8658
Abstract: T cell quiescence is essential for maintaining a broad repertoire against a large pool of diverse antigens from microbes and tumors, but the underlying molecular mechanisms remain largely unknown. We show here that CD8α is… read more here.
Keywords: interaction; cell; cell quiescence; cd8 cell ... See more keywords
Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.971045
Abstract: FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological and pathological processes including cancer. However, despite its importance the role of FOXP1 in T-cells has not been extensively studied. Although… read more here.
Keywords: cell; role foxp1; role; cell quiescence ... See more keywords