RadSigBench: a framework for benchmarking functional genomics signatures of cancer cell radiosensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbab561
Abstract: Abstract Multiple transcriptomic predictors of tumour cell radiosensitivity (RS) have been proposed, but they have not been benchmarked against one another or to control models. To address this, we present RadSigBench, a comprehensive benchmarking framework… read more here.
Keywords: cell; framework; cancer cell; cell radiosensitivity ... See more keywords
MicroRNA-613 Enhances Nasopharyngeal Carcinoma Cell Radiosensitivity via the DNA Methyltransferase 3B/Tissue Inhibitor of Matrix Metalloproteinase-3/Signal Transducer and Activator of Transcription-1/Forkhead Box O-1 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/5699275
Abstract: Nasopharyngeal carcinoma (NPC) is a common malignancy of the nasopharynx, and radioresistant represents the main obstacle in NPC treatment. Malignant transformation of normal cells is driven by genetic and epigenetic changes, which are primarily manifested… read more here.
Keywords: nasopharyngeal carcinoma; mir 613; cell; c666 ... See more keywords
Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-22-0037
Abstract: A fundamental component of cellular radioresponse is the translational control of gene expression. As a critical regulator of translational control is the eIF4F cap binding complex, we investigated whether eIF4A, the RNA helicase component of… read more here.
Keywords: sds 021; eif4a; cell radiosensitivity; tumor ... See more keywords