CMV drives the expansion of highly functional memory T cells expressing NK‐cell receptors in renal transplant recipients
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747018
Abstract: Cytomegalovirus (CMV) is a common opportunistic infection encountered in renal transplant recipients (RTRs) and may be reactivated without symptoms at any time post‐transplant. We describe how active and latent CMV affect T‐cell subsets in RTRs… read more here.
Keywords: cmv; transplant; renal transplant; cell receptors ... See more keywords
Methods for Construction of Yeast Display Libraries of Four-Domain T-Cell Receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9853-1_13
Abstract: Since two decades, yeast display methodology is a popular tool for discovery, stability improvement, and affinity maturation of diverse protein scaffolds, intended for antigen recognition. Yeast display is particularly well suited for the selection of… read more here.
Keywords: methods construction; yeast display; display; cell receptors ... See more keywords
MHC Molecules, T cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins-Key Elements of Adaptive and Innate Immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_2
Abstract: Molecules encoded by the Major Histocompatibility Complex (MHC) bind self or foreign peptides and display these at the cell surface for recognition by receptors on T lymphocytes (designated T cell receptors-TCR) or on natural killer… read more here.
Keywords: mhc molecules; natural killer; cell receptors; mhc ... See more keywords
Lipids hide or step aside for CD1-autoreactive T cell receptors.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.04.013
Abstract: Peptide and lipid antigens are presented to T cells when bound to MHC or CD1 proteins, respectively. The general paradigm of T cell antigen recognition is that T cell receptors (TCRs) co-recognize an epitope comprised… read more here.
Keywords: hide step; lipids hide; cd1 autoreactive; antigen ... See more keywords
Tuning up T-cell receptors
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.4009
Abstract: T-cell receptors with higher affinity for tumor antigens are discovered by harnessing T-cell development. read more here.
Keywords: cell; tuning cell; cell receptors;
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27669-8
Abstract: T cells play a vital role in combatting SARS-CoV-2 and forming long-term memory responses. Whereas extensive structural information is available on neutralizing antibodies against SARS-CoV-2, such information on SARS-CoV-2-specific T-cell receptors (TCRs) bound to their… read more here.
Keywords: public private; sars cov; spike epitopes; cov spike ... See more keywords
Generation of 3D cellular spheroids using DNA modified cell receptors and programmable DNA interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm01193f
Abstract: 3D culture is known to provide more faithful tissue models than 2D culture, and thus it is a valuable tool for in vitro evaluation of biological models. However, many cell lines are unable to form… read more here.
Keywords: spheroids using; dna; using dna; generation cellular ... See more keywords
Characterization of T cell receptors reactive to HCRTNH2, pHA273-287, and NP17-31 in control and narcolepsy patients
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205797119
Abstract: Significance Amidated hypocretin peptides (HCRTNH2) are autoantigens in narcolepsy type 1, an autoimmune disorder targeting HCRT neurons. The autoimmune process can be initiated by exposure to the influenza A flu, and a particular piece of… read more here.
Keywords: reactive hcrtnh2; narcolepsy patients; characterization cell; cell receptors ... See more keywords
Affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1532759
Abstract: ABSTRACT Circulating T-cells that have passed thymic selection generally bear T-cell receptors (TCRs) with sub-optimal affinity for cancer-associated antigens, resulting in a limited ability to detect and eliminate tumor cells. Engineering TCRs to increase their… read more here.
Keywords: affinity enhanced; cell receptors; strategy; mage a10 ... See more keywords
Non‐KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12523
Abstract: Natural killer (NK) cells are of major significance in patients after allogeneic haematopoietic stem cell transplantation (HSCT). They are the first subset of lymphocytes to appear in peripheral blood after transplantation and play an important… read more here.
Keywords: transplantation; allogeneic haematopoietic; role; cell receptors ... See more keywords
Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights
Sign Up to like & getrecommendations! Published in 2022 at "Open Life Sciences"
DOI: 10.1515/biol-2022-0075
Abstract: Abstract Osteoarthritis (OA) is a chronic arthritic disease characterized by cartilage degradation, synovial inflammation, and subchondral bone lesions. The studies on the pathogenesis of OA are complex and diverse. The roles of receptors signaling in… read more here.
Keywords: pathogenesis osteoarthritis; osteoarthritis current; effect cell; current insights ... See more keywords