Predicting CD4 T‐Cell Reconstitution Following Pediatric Hematopoietic Stem Cell Transplantation
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.621
Abstract: Hematopoietic stem cell transplantation (HSCT) is an increasingly common treatment for children with a range of hematological disorders. Conditioning with cytotoxic chemotherapy and total body irradiation leaves patients severely immunocompromised. T‐cell reconstitution can take several… read more here.
Keywords: cell reconstitution; reconstitution; stem cell; transplantation ... See more keywords
Effect of different rituximab regimens on B cell depletion and time to relapse in children with steroid-dependent nephrotic syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-4052-x
Abstract: BackgroundSeveral studies have demonstrated that rituximab (RTX) improves relapse-free survival in patients with steroid-dependent nephrotic syndrome (SDNS). However, these studies used various RTX regimens and there are few data comparing these regimens in children with… read more here.
Keywords: group; time cell; time; relapse ... See more keywords
Prospective Open-Label Phase II Trial of Individualized Anti-Thymocyte Globulin for Improved T-Cell Reconstitution after Pediatric Allogeneic Hematopoietic Cell Transplantation: The Parachute-Study
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.577
Abstract: Introduction Rabbit anti-thymocyte globulin (ATG) is used in allogeneic hematopoietic cell transplantation (HCT) to prevent graft-versus-host-disease (GvHD) and graft failure (GF). Its main and unpredictable toxicity includes poor immune reconstitution associated with increased relapse, viral… read more here.
Keywords: anti thymocyte; thymocyte globulin; cell reconstitution; reconstitution ... See more keywords
Activation of the Zinc-sensing receptor GPR39 promotes T cell reconstitution after hematopoietic cell transplant in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021013950
Abstract: Prolonged lymphopenia represents a major clinical problem after cytoreductive therapies such as chemotherapy and the conditioning required for hematopoietic stem cell transplant (HSCT), contributing toward the risk of infections and malignant relapse. Restoration of T… read more here.
Keywords: gpr39; cell transplant; hsct; receptor gpr39 ... See more keywords
Benefits of Prophylactic Short-Course Immune Tolerance Induction in Patients With Infantile Pompe Disease: Demonstration of Long-Term Safety and Efficacy in an Expanded Cohort
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01727
Abstract: Immune tolerance induction (ITI) with a short-course of rituximab, methotrexate, and/or IVIG in the enzyme replacement therapy (ERT)-naïve setting has prolonged survival and improved clinical outcomes in patients with infantile Pompe disease (IPD) lacking endogenous… read more here.
Keywords: rituximab; short course; cell reconstitution; cohort ... See more keywords