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Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2019.01.008
Abstract: The redirection of T cell activity towards cancer cells via targeting of tumor-associated antigens (TAAs) by soluble bispecific antibodies (bsAbs) or membrane-anchored chimeric antigen receptors is one of the most promising cancer immunotherapy strategies currently…
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Keywords:
cell redirecting;
redirecting strategies;
bispecific antibodies;
stab tumors ... See more keywords
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Published in 2023 at "Journal of Immunotherapy (Hagerstown, Md. : 1997)"
DOI: 10.1097/cji.0000000000000453
Abstract: T-cell immunotherapies are promising strategies to generate T-cell responses towards tumor-derived or pathogen-derived antigens. Adoptive transfer of T cells genetically modified to express antigen receptor transgenes has shown promise for the treatment of cancer. However,…
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Keywords:
cell redirecting;
cell;
redirecting therapies;
tcr ... See more keywords
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Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn4613
Abstract: Extensive antibody engineering and cloning is typically required to generate new bispecific antibodies. Made-to-order genes, advanced expression systems, and high-efficiency cloning can simplify and accelerate this process, but it still can take months before a…
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Keywords:
cell redirecting;
shelf;
site specific;
site ... See more keywords
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Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-0470
Abstract: T-cell–redirecting therapies are promising new therapeutic options in the field of cancer immunotherapy, but the development of these modalities is challenging. A commonly observed adverse event in patients treated with T-cell–redirecting therapies is cytokine release…
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Keywords:
patient;
redirecting therapies;
risk;
patient risk ... See more keywords
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Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-4555
Abstract: T-cell redirecting bispecific antibodies are an emerging class of therapeutic agents designed to simultaneously bind to T cells (via CD3) and tumor cell specific antigens (TSA), with the goal of inducing T cell-mediated killing of…
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Keywords:
cd3;
biodistribution;
cell redirecting;
affinity ... See more keywords
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Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010132
Abstract: T cell-redirecting strategies have emerged as effective cancer immunotherapy approaches. Bispecific antibodies (bsAbs) are designed to specifically recruit T cells to the tumor microenvironment and induce the assembly of the immunological synapse (IS) between T…
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Keywords:
organization;
cell redirecting;
redirecting strategies;
cancer immunotherapy ... See more keywords