Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.047
Abstract: Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction… read more here.
Keywords: cell repertoire; maternal antibodies; early life; responses vaccination ... See more keywords
T-cell repertoire analysis and metrics of diversity and clonality.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.07.010
Abstract: The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated the understanding of the complexity of immune repertoire dynamics combined to transcriptomics. Also, profiling of cellular repertoires in health or disease requires statistical metrics… read more here.
Keywords: cell repertoire; repertoire analysis; diversity; repertoire ... See more keywords
IMMU-11. SPATIOTEMPORAL IMMUNOGENOMIC ANALYSIS OF THE T-CELL REPERTOIRE IN IDH-MUTANT LOWER GRADE GLIOMAS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.505
Abstract: The design and evaluation of immunotherapies in IDH-mutant lower grade gliomas (LGG) is hindered by a poor understanding of the LGG T-cell repertoire. We present data on the temporal evolution, intratumoral spatial distribution, and prognostic… read more here.
Keywords: cell repertoire; gliomas; glioma; grade ... See more keywords
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat0381
Abstract: Inspection of the naive B cell repertoire specific for an HIV vaccine immunogen provides actionable information for human vaccine design and advancement. Learning from naive B cells Despite decades of intensive research, HIV vaccines are… read more here.
Keywords: cell repertoire; human naive; naive cell; vaccine ... See more keywords
Long-term Sculpting of the B-cell Repertoire following Cancer Immunotherapy in Patients Treated with Sipuleucel-T
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-20-0252
Abstract: Sipuleucel-T, an autologous cell–based immunotherapy, improves survival in castration-resistant prostate cancer patients, yet how this therapy induces antitumor B-cell immunity remains unclear. Sipuleucel-T induces long-term immune memory and lasting changes to the B-cell repertoire. Sipuleucel-T… read more here.
Keywords: cell repertoire; cancer; sipuleucel; long term ... See more keywords
Network Representation of T-Cell Repertoire— A Novel Tool to Analyze Immune Response to Cancer Formation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02913
Abstract: The T cell repertoire potentially presents complexity compatible, or greater than, that of the human brain. T cell based immune response is involved with practically every part of human physiology, and high-throughput biology needed to… read more here.
Keywords: cell repertoire; network; immune response; cancer ... See more keywords
Changes in the NK Cell Repertoire Related to Initiation of TB Treatment and Onset of Immune Reconstitution Inflammatory Syndrome in TB/HIV Co-infected Patients in Rio de Janeiro, Brazil—ANRS 12274
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01800
Abstract: Tuberculosis (TB) is the most common comorbidity and the leading cause of death among HIV-infected individuals. Although the combined antiretroviral therapy (cART) during TB treatment improves the survival of TB/HIV patients, the occurrence of immune… read more here.
Keywords: cell repertoire; hiv patients; treatment; hiv ... See more keywords
Drug and Chemical Allergy: A Role for a Specific Naive T-Cell Repertoire?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.653102
Abstract: Allergic reactions to drugs and chemicals are mediated by an adaptive immune response involving specific T cells. During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells.… read more here.
Keywords: drug; cell repertoire; drug chemical; allergy ... See more keywords
T-Cell Repertoire Characteristics of Asymptomatic and Re-Detectable Positive COVID-19 Patients
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.769442
Abstract: The prevention of the COVID-19 pandemic is highly complicated by the prevalence of asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic and convalescent patients, while the immune responses in asymptomatic patients… read more here.
Keywords: positive cases; detectable positive; repertoire characteristics; covid ... See more keywords
Perturbations in the T cell receptor β repertoire during malaria infection in children: A preliminary study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.971392
Abstract: The changes occurring in the T cell repertoire during clinical malaria infection in children remain unknown. In this study, we undertook the first detailed comparative study of the T cell repertoire in African children with… read more here.
Keywords: malaria infection; infection; infection children; cell repertoire ... See more keywords
The liver-resident immune cell repertoire - A boon or a bane during machine perfusion?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.982018
Abstract: The liver has been proposed as an important “immune organ” of the body, as it is critically involved in a variety of specific and unique immune tasks. It contains a huge resident immune cell repertoire,… read more here.
Keywords: cell; machine; immune cell; cell repertoire ... See more keywords