Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation
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DOI: 10.1002/advs.202401385
Abstract: Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency primarily due to autoimmune destruction of pancreatic β‐cells. The prevailing treatment for T1DM involves daily subcutaneous insulin injections, but a substantial proportion of patients… read more here.
Keywords: immunoprotection strategies; islet; xenotransplantation; islet xenotransplantation ... See more keywords
Immunological Issues After Stem Cell-Based β Cell Replacement
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DOI: 10.1007/s11892-017-0901-4
Abstract: Purpose of ReviewIslet and pancreas transplantation prove that β cell replacement can cure the glycemic derangements in type 1 diabetes (T1D). Induced pluripotent stem cells (iPSCs) can differentiate into functional insulin-producing cells, able to restore… read more here.
Keywords: cell replacement; stem cell; immunological issues; issues stem ... See more keywords
Perceptions of the Benefits and Risks of Novel Therapies for Type 1 Diabetes: A Qualitative Study
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DOI: 10.1007/s13300-025-01783-y
Abstract: Novel therapies, including disease-modifying and cell replacement therapies, may preserve or replace beta cells in people with type 1 diabetes. This study sought to understand how people living with type 1 diabetes or caring for… read more here.
Keywords: novel therapies; replacement therapies; type diabetes; disease modifying ... See more keywords
Efficacy of Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cell Replacement Therapy in a Vascular Dementia Animal Model
Sign Up to like & getrecommendations! Published in 2025 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-025-00706-z
Abstract: Cell replacement therapy is the only treatment that restores or repairs the function of impaired tissues in neurodegenerative diseases, including vascular dementia (VaD); however, current VaD treatments focus on slowing or mitigating the underlying small… read more here.
Keywords: vascular dementia; group; replacement therapy; cell ... See more keywords
Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease
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DOI: 10.1016/j.jcyt.2020.06.001
Abstract: Background Cell replacement therapy (CRT) for Huntington disease (HD) requires a source of striatal (STR) progenitors capable of restoring the function lost due to STR degeneration. Authentic STR progenitors can be collected from the fetal… read more here.
Keywords: cell replacement; source; str; donor ... See more keywords
&bgr; Cell Replacement Therapy: The Next 10 Years
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DOI: 10.1097/tp.0000000000001937
Abstract: Abstract &bgr; cell replacement with either pancreas or islet transplantation has progressed immensely over the last decades with current 1- and 5-year insulin independence rates of approximately 85% and 50%, respectively. Recent advances are largely… read more here.
Keywords: bgr cell; cell replacement; pancreas islet;
Two‐pronged approach: Therapeutic effect of biological scaffold combined with immune intervention and β‐cell replacement on type 1 diabetic mice
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.1111/dom.16373
Abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by β‐cell damage and absolute insulin deficiency. We consider combining immune intervention and β‐cell replacement by biological scaffold to treat T1DM. Zinc transporter 8 (ZnT8)… read more here.
Keywords: scaffold; immune intervention; intervention cell; cell ... See more keywords
Advances in insulin therapy from discovery to β‐cell replacement
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13902
Abstract: Insulin therapy using insulin purified from porcine or bovine pancreas revolutionized diabetes therapy in the 1920s. A series of advances including cloning human insulin cDNA enabled the development of recombinant human insulin with improved features.… read more here.
Keywords: advances insulin; insulin therapy; cell replacement;
Abstract WMP111: Progranulin Enhances the Engraftment of Transplanted Human induced Pluripotent Stem Cell-derived Cerebral Neurons in Cell Replacement Therapy
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DOI: 10.1161/str.56.suppl_1.wmp111
Abstract: Background: Stroke or traumatic brain injury (TBI), due to damage to the cerebral motor cortex, often results in significant motor dysfunction and disabilities. Cell replacement therapy emerges as a prospective alternative treatment, promising to restore… read more here.
Keywords: replacement therapy; human induced; cell; induced pluripotent ... See more keywords
The Last Mile in Beta-Cell Replacement Therapy for Type 1 Diabetes: Time to Grow Up
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DOI: 10.3389/ti.2025.14565
Abstract: Beta cell replacement therapy for type 1 diabetes (T1D) is undergoing a transformative shift, driven by advances in stem cell biology, gene editing, and tissue engineering. While islet transplantation has demonstrated proof-of-concept success in restoring… read more here.
Keywords: cell; beta cell; cell replacement; replacement therapy ... See more keywords
Endogenous versus exogenous cell replacement for Parkinson’s disease: where are we at and where are we going?
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.336137
Abstract: Parkinson’s disease is the second most common neurodegenerative disease and has currently no effective treatment, one that would be able to stop or reverse the loss of dopaminergic neurons in the substantia nigra pars compacta.… read more here.
Keywords: disease; parkinson disease; cell replacement;