Genetics: Towards β-cell regeneration
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2017.140
Abstract: very challenging; although harmine analogues can induce β-cell replication, the low rate of replication means that they are unlikely to be useful for the treatment of patients with type 1 diabetes mellitus or type 2… read more here.
Keywords: genetics; type diabetes; diabetes mellitus; cell replication ... See more keywords
CC-401 Promotes &bgr;-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00083
Abstract: Pharmacologic expansion of endogenous β cells is a promising therapeutic strategy for diabetes. To elucidate the molecular pathways that control β-cell growth we screened ∼2400 bioactive compounds for rat β-cell replication-modulating activity. Numerous hit compounds… read more here.
Keywords: cell replication; replication via; cell; replication ... See more keywords
Exogenous Lactogenic Signaling Stimulates Beta Cell Replication In Vivo and In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020215
Abstract: As patients recently diagnosed with T1D and patients with T2D have residual beta cell mass, there is considerable effort in beta cell biology to understand the mechanisms that drive beta cell regeneration as a potential… read more here.
Keywords: cell; pseudopregnancy; beta cell; cell replication ... See more keywords