Changing Fate: Reprogramming Cells via Engineered Nanoscale Delivery Materials
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202108757
Abstract: The incorporation of nanotechnology in regenerative medicine is at the nexus of fundamental innovations and early‐stage breakthroughs, enabling exciting biomedical advances. One of the most exciting recent developments is the use of nanoscale constructs to… read more here.
Keywords: materials changing; medicine; fate; delivery ... See more keywords
An Optogenetic‐Controlled Cell Reprogramming System for Driving Cell Fate and Light‐Responsive Chimeric Mice
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202858
Abstract: Pluripotent stem cells (PSCs) hold great promise for cell‐based therapies, disease modeling, and drug discovery. Classic somatic cell reprogramming to generate induced pluripotent stem cells (iPSCs) is often achieved based on overexpression of transcription factors… read more here.
Keywords: system; cell; cell fate; mice ... See more keywords
Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury
Sign Up to like & getrecommendations! Published in 2017 at "Protein & Cell"
DOI: 10.1007/s13238-017-0373-y
Abstract: Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive. Here we identified combination of small chemical compounds including drug… read more here.
Keywords: drug cocktails; cell reprogramming; robustly promoting; chemical compounds ... See more keywords
Nac1 facilitates pluripotency gene activation for establishing somatic cell reprogramming.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.043
Abstract: Transcription factors play a central role in pluripotency transcription circuitry for establishing pluripotent reprogramming. Master transcription factors Oct4, Nanog, and Sox2 are known to form the core of the pluripotency transcription network. Other transcription factors… read more here.
Keywords: transcription; somatic cell; cell reprogramming; pluripotency ... See more keywords
Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46359-6
Abstract: The signaling mechanisms controlling somatic cell reprogramming are not fully understood. In this study, we report a novel role for mitochondrial Akt1 signaling that enhanced somatic cell reprogramming efficiency. The role of mitochondrial Akt1 in… read more here.
Keywords: somatic cell; cell reprogramming; mito akt1; akt1 ... See more keywords
Effect of small molecules on cell reprogramming.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c6mb00595k
Abstract: The essential idea of regenerative medicine is to fix or replace tissues or organs with alive and patient-specific implants. Pluripotent stem cells are able to indefinitely self-renew and differentiate into all cell types of the… read more here.
Keywords: medicine; cell reprogramming; small molecules; effect small ... See more keywords
Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming
Sign Up to like & getrecommendations! Published in 2017 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2017.0161
Abstract: Abstract Cytotoxic T cells are critical in controlling virus infections. However, continuous antigen stimulation and negative regulatory factors cause CD8 T cells to enter a dysfunctional state (T cell exhaustion), resulting in viral persistence. We… read more here.
Keywords: purging exhausted; somatic cell; cell reprogramming; exhausted virus ... See more keywords
Fluorescent Reporters Distinguish Stem Cell Colony Subtypes During Somatic Cell Reprogramming
Sign Up to like & getrecommendations! Published in 2022 at "Cellular Reprogramming"
DOI: 10.1089/cell.2022.0071
Abstract: Somatic cell reprogramming was first developed to create induced pluripotent stem (iPS) cells. Since that time, the highly dynamic and heterogeneous nature of the reprogramming process has come to be appreciated. Remarkably, a distinct type… read more here.
Keywords: cell; stem cell; fluorescent reporters; somatic cell ... See more keywords
Somatic Cell Reprogramming Informed by the Oocyte.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cells and development"
DOI: 10.1089/scd.2018.0066
Abstract: The successful production of animals and embryonic stem cells using somatic cell nuclear transfer (SCNT) has demonstrated the unmatched nuclear reprogramming capacity of the oocyte and helped prove the degree of plasticity of differentiated cells.… read more here.
Keywords: somatic cell; cell; cell reprogramming; informed oocyte ... See more keywords
SMN Enhances Pluripotent Genes Expression and Facilitates Cell Reprogramming.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells and development"
DOI: 10.1089/scd.2022.0091
Abstract: Survival motor neuron (SMN) plays important roles in snRNPs assembly and mRNA splicing. Deficiency of SMN causes spinal muscular atrophy (SMA), a leading genetic disease of childhood mortality. Previous studies have shown that SMN regulates… read more here.
Keywords: smn enhances; pluripotent genes; expression; smn ... See more keywords
Computational approaches for direct cell reprogramming: from the bulk omics era to the single cell era
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Functional Genomics"
DOI: 10.1093/bfgp/elac008
Abstract: Abstract Recent advances in direct cell reprogramming have made possible the conversion of one cell type to another cell type, offering a potential cell-based treatment to many major diseases. Despite much attention, substantial roadblocks remain… read more here.
Keywords: cell; transcription; single cell; transcription factor ... See more keywords