Corticogenesis across species at single‐cell resolution
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22896
Abstract: The neocortex (or pallium) consists of diverse cell types that are organized in a highly species‐specific manner under strict spatiotemporal control during development. Many of the cell types are present transiently throughout development but contribute… read more here.
Keywords: corticogenesis across; cell; cell resolution; single cell ... See more keywords
Time-Lapse Imaging of Necroptosis and DAMP Release at Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1258-3_29
Abstract: Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like protein (MLKL). Necroptotic cells release a variety of cellular and nuclear factors, referred to as danger-associated… read more here.
Keywords: single cell; necroptosis; cell; cell resolution ... See more keywords
Deconstructing gastrulation at single-cell resolution
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.02.059
Abstract: Gastrulation movements in all animal embryos start with regulated deformations of patterned epithelial sheets, which are driven by cell divisions, cell shape changes, and cell intercalations. Each of these behaviors has been associated with distinct… read more here.
Keywords: gastrulation single; deconstructing gastrulation; gastrulation; cell ... See more keywords
Reading the heart at single-cell resolution.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.08.010
Abstract: The burgeoning field of single-cell transcriptomics augments our ability to scrutinize organ systems at unprecedented resolutions. Single-cell RNA sequencing (scRNA-seq) and analytical techniques have shed light on the cellular heterogeneity, developmental trajectories, intercellular communications of… read more here.
Keywords: single cell; scrna seq; reading heart; heart single ... See more keywords
Exogenous Metals Atlas in Spermatozoa at Single-Cell Resolution in Relation to Human Semen Quality.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c08838
Abstract: While exogenous metal/metalloid (metal) exposure has been associated with reduced human semen quality, no study has assessed the associations of exogenous metals in human spermatozoa with semen quality. Here, we developed a strategy to explore… read more here.
Keywords: semen quality; exogenous metals; cell resolution; single cell ... See more keywords
Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution
Sign Up to like & getrecommendations! Published in 2020 at "Cell Research"
DOI: 10.1038/s41422-020-00401-9
Abstract: Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic and epigenetic information through generations. The transcriptional landscapes of human FGC development have been revealed; however, the epigenetic reprogramming process… read more here.
Keywords: single cell; fetal germ; cell; development ... See more keywords
Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0475-2
Abstract: Mapping of the holistic cell behaviours sculpting the four-chambered mammalian heart has been a goal or previous studies, but so far only success in transparent invertebrates and lower vertebrates with two-chambered hearts has been achieved.… read more here.
Keywords: single cell; chamber formation; cell; ventricle chamber ... See more keywords
Deciphering the endometrial niche of human thin endometrium at single-cell resolution
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115912119
Abstract: Significance Thin endometrium is the most common reason for uterine infertility and refractory gynecological diseases due to its complexity in pathogenesis and adverse pregnancy outcomes. Here, we profile cells from normal and thin endometrium at… read more here.
Keywords: endometrium; thin endometrium; single cell; endometrium single ... See more keywords
Understanding human gut diseases at single-cell resolution
Sign Up to like & getrecommendations! Published in 2020 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddaa130
Abstract: Abstract Our understanding of gut functioning and pathophysiology has grown considerably in the past decades, and advancing technologies enable us to deepen this understanding. Single-cell RNA sequencing (scRNA-seq) has opened a new realm of cellular… read more here.
Keywords: single cell; gut; human gut; understanding human ... See more keywords
LnCeCell: a comprehensive database of predicted lncRNA-associated ceRNA networks at single-cell resolution
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1017
Abstract: Abstract Within the tumour microenvironment, cells exhibit different behaviours driven by fine-tuning of gene regulation. Identification of cellular-specific gene regulatory networks will deepen the understanding of disease pathology at single-cell resolution and contribute to the… read more here.
Keywords: single cell; lncecell; cerna; lncrna associated ... See more keywords
The accessible chromatin landscape of the murine hippocampus at single-cell resolution.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.243725.118
Abstract: Here we present a comprehensive map of the accessible chromatin landscape of the mouse hippocampus at single-cell resolution. Substantial advances of this work include the optimization of a single-cell combinatorial indexing assay for transposase accessible… read more here.
Keywords: single cell; accessible chromatin; landscape; cell ... See more keywords