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   Articles with "cell resolution" as a keyword



From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

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recommendations! Published in 2025 at "Febs Letters"

DOI: 10.1002/1873-3468.70162

Abstract: This study, based on datasets from healthy tissues, lactating mammary epithelial cells, and breast cancer phenotypes, investigates mammary gland pathophysiology at single‐cell resolution to identify key regulators in breast cancer development and to gain a… read more here.

Keywords: breast cancer; breast; single cell; cell resolution ... See more keywords

Corticogenesis across species at single‐cell resolution

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recommendations! Published in 2022 at "Developmental Neurobiology"

DOI: 10.1002/dneu.22896

Abstract: The neocortex (or pallium) consists of diverse cell types that are organized in a highly species‐specific manner under strict spatiotemporal control during development. Many of the cell types are present transiently throughout development but contribute… read more here.

Keywords: corticogenesis across; cell; cell resolution; single cell ... See more keywords

Improving Spatial Transcriptomics with Membrane‐Based Boundary Definition and Enhanced Single‐Cell Resolution

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recommendations! Published in 2025 at "Small Methods"

DOI: 10.1002/smtd.202401056

Abstract: Accurately defining cell boundaries for spatial transcriptomics is technically challenging. The current major approaches are nuclear staining or mathematical inference, which either exclude the cytoplasm or determine a hypothetical boundary. Here, a new method is… read more here.

Keywords: membrane based; spatial transcriptomics; single cell; cell resolution ... See more keywords
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Time-Lapse Imaging of Necroptosis and DAMP Release at Single-Cell Resolution.

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recommendations! Published in 2021 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-1258-3_29

Abstract: Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like protein (MLKL). Necroptotic cells release a variety of cellular and nuclear factors, referred to as danger-associated… read more here.

Keywords: single cell; necroptosis; cell; cell resolution ... See more keywords

Deconstructing gastrulation at single-cell resolution

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recommendations! Published in 2022 at "Current Biology"

DOI: 10.1016/j.cub.2022.02.059

Abstract: Gastrulation movements in all animal embryos start with regulated deformations of patterned epithelial sheets, which are driven by cell divisions, cell shape changes, and cell intercalations. Each of these behaviors has been associated with distinct… read more here.

Keywords: gastrulation single; deconstructing gastrulation; gastrulation; cell ... See more keywords
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Reading the heart at single-cell resolution.

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recommendations! Published in 2020 at "Journal of molecular and cellular cardiology"

DOI: 10.1016/j.yjmcc.2020.08.010

Abstract: The burgeoning field of single-cell transcriptomics augments our ability to scrutinize organ systems at unprecedented resolutions. Single-cell RNA sequencing (scRNA-seq) and analytical techniques have shed light on the cellular heterogeneity, developmental trajectories, intercellular communications of… read more here.

Keywords: single cell; scrna seq; reading heart; heart single ... See more keywords

Exogenous Metals Atlas in Spermatozoa at Single-Cell Resolution in Relation to Human Semen Quality.

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recommendations! Published in 2023 at "Environmental science & technology"

DOI: 10.1021/acs.est.2c08838

Abstract: While exogenous metal/metalloid (metal) exposure has been associated with reduced human semen quality, no study has assessed the associations of exogenous metals in human spermatozoa with semen quality. Here, we developed a strategy to explore… read more here.

Keywords: semen quality; exogenous metals; cell resolution; single cell ... See more keywords
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Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution

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recommendations! Published in 2020 at "Cell Research"

DOI: 10.1038/s41422-020-00401-9

Abstract: Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic and epigenetic information through generations. The transcriptional landscapes of human FGC development have been revealed; however, the epigenetic reprogramming process… read more here.

Keywords: single cell; fetal germ; cell; development ... See more keywords
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Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution

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recommendations! Published in 2020 at "Nature Cell Biology"

DOI: 10.1038/s41556-020-0475-2

Abstract: Mapping of the holistic cell behaviours sculpting the four-chambered mammalian heart has been a goal or previous studies, but so far only success in transparent invertebrates and lower vertebrates with two-chambered hearts has been achieved.… read more here.

Keywords: single cell; chamber formation; cell; ventricle chamber ... See more keywords

Spotiphy enables single-cell spatial whole transcriptomics across an entire section

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recommendations! Published in 2025 at "Nature Methods"

DOI: 10.1038/s41592-025-02622-5

Abstract: Spatial transcriptomics (ST) has advanced our understanding of tissue regionalization by enabling the visualization of gene expression within whole-tissue sections, but current approaches remain plagued by the challenge of achieving single-cell resolution without sacrificing whole-genome… read more here.

Keywords: single cell; cell resolution; spotiphy; histology ... See more keywords

Deciphering the endometrial niche of human thin endometrium at single-cell resolution

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2115912119

Abstract: Significance Thin endometrium is the most common reason for uterine infertility and refractory gynecological diseases due to its complexity in pathogenesis and adverse pregnancy outcomes. Here, we profile cells from normal and thin endometrium at… read more here.

Keywords: endometrium; thin endometrium; single cell; endometrium single ... See more keywords