Omicron-Specific Cytotoxic T-Cell Responses After a Third Dose of mRNA COVID-19 Vaccine Among Patients With Multiple Sclerosis Treated With Ocrelizumab.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.0245
Abstract: Importance The SARS-CoV-2 variant B.1.1.529 (Omicron) escapes neutralizing antibodies elicited after COVID-19 vaccination, while T-cell responses might be better conserved. It is crucial to assess how a third vaccination modifies these responses, particularly for immunocompromised… read more here.
Keywords: cell; cell responses; omicron; vaccination ... See more keywords
Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14625
Abstract: Autoimmune polyendocrine syndrome type I (APS‐1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against tissue proteins and cytokines. We here hypothesised… read more here.
Keywords: syndrome type; cell; autoimmune polyendocrine; polyendocrine syndrome ... See more keywords
Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8+ T Cell Responses
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Science"
DOI: 10.1002/advs.201700426
Abstract: Abstract Due to its safety and efficacy, aluminum hydroxide is used as an immune adjuvant in human vaccines for over 80 years. Being a Th2 stimulator, the classical gel‐like adjuvant, however, fails to generate CD8+… read more here.
Keywords: cd8 cell; cell responses; turning old; gel ... See more keywords
Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T-Cell Responses.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202103023
Abstract: Short peptides reflecting major histocompatibility complex (MHC) class I (MHC-I) epitopes frequently lack sufficient immunogenicity to induce robust antigen (Ag)-specific CD8+ T cell responses. In the current work, it is demonstrated that position-scanning peptide libraries… read more here.
Keywords: cd8 cell; cell responses; cd8; position scanning ... See more keywords
Monocytic myeloid‐derived suppressor cells regulate T‐cell responses against vaccinia virus
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646797
Abstract: Vaccinia virus (VV) can potently activate NK‐ and T‐cell responses, leading to efficient viral control and generation of long‐lasting protective immunity. However, immune responses against viral infections are often tightly controlled to avoid collateral damage… read more here.
Keywords: myeloid derived; cell responses; infection; mdscs ... See more keywords
Dysregulation in B‐cell responses and T follicular helper cell function in ADA2 deficiency patients
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048549
Abstract: Adenosine deaminase 2 deficiency (DADA2) is an autoinflammatory disease characterized by inflammatory vasculopathy, early strokes associated often with hypogammaglobulinemia. Pure red cell aplasia, thrombocytopenia, and neutropenia have been reported. The defect is due to biallelic… read more here.
Keywords: cell responses; cell; cell function; function ada2 ... See more keywords
Human vascular cell responses to the circulating bone hormone osteocalcin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28707
Abstract: The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial… read more here.
Keywords: cell responses; human vascular; vascular cell; cell ... See more keywords
Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell‐based therapeutics?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.mr0718-303r
Abstract: NK cells play a critical role in antiviral and antitumor responses. Although current NK cell immune therapies have focused primarily on cancer biology, many of these advances can be readily applied to target HIV/simian immunodeficiency… read more here.
Keywords: biology; hiv siv; siv infections; cell ... See more keywords
T‐cell responses to SARS‐CoV‐2 Omicron spike epitopes with mutations after the third booster dose of an inactivated vaccine
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27814
Abstract: The rapidly spreading severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron variant contains more than 30 mutations that mediate escape from antibody responses elicited by prior infection or current vaccines. Fortunately, T‐cell responses are highly… read more here.
Keywords: omicron spike; cell responses; booster; cov omicron ... See more keywords
Immunodominant SARS‐CoV‐2‐specific CD4+ and CD8+ T‐cell responses elicited by inactivated vaccines in healthy adults
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28743
Abstract: Safety profiles and humoral responses to inactivated severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines have been previously assessed, but cellular immune responses to inactivated SARS‐CoV‐2 vaccines remain understudied. Here, we report the comprehensive characteristics… read more here.
Keywords: cell responses; cd4; cov specific; sars cov ... See more keywords
Tumor-Specific CD8+ T-Cell Responses Induced by DNA Vaccination.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0872-2_12
Abstract: DNA vaccines assisted by electroporation efficiently trigger antitumor cytotoxic CD8+ T cell responses in preclinical cancer models and hold potential for human use. They can be easily engineered to express either tumor-associated self-antigens, which are… read more here.
Keywords: cd8 cell; cell responses; tumor specific; tumor ... See more keywords