Regulation of Protein Conformation Enables Cell‐Selective Targeting of Virus‐Mimicking Nanoparticles for siRNA Therapy of Glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202401640
Abstract: Orthotopic glioblastoma (GBM) has an aggressive growth pattern and complex pathogenesis, becoming one of the most common and deadly tumors of the central nervous system (CNS). The emergence of RNA therapies offers promise for the… read more here.
Keywords: virus mimicking; cell selective; selective targeting; gbm ... See more keywords
Cell-selective titanium oxide coatings mediated by coupling hafnium-doping and UV pre-illumination
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2019.07.001
Abstract: Abstract Cell-selective biomaterials, i.e. favoring the functions of gingival cells and simultaneously reducing the adhesion of pathogenic bacteria, is highly desired in dental implants. However, due to the same mechanisms shared in attachment by mammalian… read more here.
Keywords: titanium oxide; oxide coatings; titanium; illumination ... See more keywords
Bioderived Lipoic Acid-Based Dynamic Covalent Nanonetworks of Poly(disulfide)s: Enhanced Encapsulation Stability and Cancer Cell-Selective Delivery of Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00493
Abstract: Dynamic covalent poly(disulfide)-based cross-linked nanoaggregates, termed nanonetworks (NNs), endowed with pH- and redox-responsive degradation features have been fabricated for stable noncovalent encapsulation and triggered cargo release in a controlled fashion. A bioderived lipoic acid-based Gemini… read more here.
Keywords: dynamic covalent; cell selective; encapsulation; stability ... See more keywords
Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01876
Abstract: Antimicrobial peptides are promising molecules in uprising consequences of drug-resistant bacteria. The prodomain of furin, a serine protease, expressed in all vertebrates including humans, is known to be important for physiological functions. Here, potent antimicrobial… read more here.
Keywords: disruption; prodomain human; furin; cell selective ... See more keywords
Cell-selective proteomics reveal novel effectors secreted by an obligate intracellular bacterial pathogen
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50493-9
Abstract: Pathogenic bacteria secrete protein effectors to hijack host machinery and remodel their infectious niche. Rickettsia spp. are obligate intracellular bacteria that can cause life-threatening disease, but their absolute dependence on the host cell has impeded… read more here.
Keywords: cell selective; host; selective proteomics; pathogen ... See more keywords
Phosphatase-triggered cell-selective release of a Pt(iv)-backboned prodrug-like polymer for an improved therapeutic index.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials science"
DOI: 10.1039/c6bm00935b
Abstract: We describe here the synthesis and cell-selective delivery of a cationic Pt(iv)-backboned prodrug-like polymer P(DSP-DAEP). P(DSP-DAEP) features excellent aqueous solubility, unusually high (44.5%) drug loading, can be rapidly reduced to release the active cisplatin, and… read more here.
Keywords: like polymer; cell selective; prodrug like; backboned prodrug ... See more keywords
3D Visualization of Human Blood Vascular Networks Using Single-Domain Antibodies Directed against Endothelial Cell-Selective Adhesion Molecule (ESAM)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084369
Abstract: High-quality three-dimensional (3D) microscopy allows detailed, unrestricted and non-destructive imaging of entire volumetric tissue specimens and can therefore increase the diagnostic accuracy of histopathological tissue analysis. However, commonly used IgG antibodies are oftentimes not applicable… read more here.
Keywords: selective adhesion; cell selective; endothelial cell; blood ... See more keywords
Toxicity of Vanadium during Development of Sea Urchin Embryos: Bioaccumulation, Calcium Depletion, ERK Modulation and Cell-Selective Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116239
Abstract: Vanadium toxicology is a topic of considerable importance as this metal is widely used in industrial and biomedical fields. However, it represents a potential emerging environmental pollutant because wastewater treatment plants do not adequately remove… read more here.
Keywords: cell selective; vanadium; toxicity; sea urchin ... See more keywords