Introduction of cell‐selectivity in bovine cathelicidin BMAP‐28 by exchanging heptadic isoleucine with the adjacent proline at a non‐heptadic position
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DOI: 10.1002/pep2.24207
Abstract: Bovine cathelicidin, BMAP‐28 exhibits potent antimicrobial activity without any cell‐selectivity. Considering the role of its C‐terminus amino acid residues in its cytotoxic activities, we envisioned to rearrange the amino acids at its C‐terminus without altering… read more here.
Keywords: cathelicidin bmap; bovine cathelicidin; position; cell selectivity ... See more keywords
LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity.
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DOI: 10.1016/j.ejmech.2017.05.028
Abstract: KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We designed and synthesized a series of d-amino acid-substituted analogs of KR-12-a5 with the aim of… read more here.
Keywords: anti inflammatory; amino acid; cell selectivity; inflammatory activity ... See more keywords
Phosphatidylserine Exposed Lipid Bilayer Models for Understanding Cancer Cell Selectivity of Natural Compounds: A Molecular Dynamics Simulation Study
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DOI: 10.3390/membranes12010064
Abstract: Development of drugs that are selectively toxic to cancer cells and safe to normal cells is crucial in cancer treatment. Evaluation of membrane permeability is a key metric for successful drug development. In this study,… read more here.
Keywords: cell; natural compounds; molecular dynamics; cancer cell ... See more keywords