Blockade of Nuclear β‐Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202528
Abstract: Colorectal cancer (CRC) is one of the most common malignant tumors in the world, with high prevalence and low 5‐year survival. Most of the CRC patients show excessive activation of the Wnt/β‐catenin pathway which is… read more here.
Keywords: nu2058; catenin; ranbp3; crc ... See more keywords
Metformin attenuates lipopolysaccharide‐induced epithelial cell senescence by activating autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11536
Abstract: Acute lung injury (ALI) is a life‐threatening medical condition with higher mortality and morbidity in elderly patients. Recently, metformin, a drug commonly used to lower blood glucose in type 2 diabetes patients, has been shown… read more here.
Keywords: epithelial cell; cell senescence; atg5; senescence ... See more keywords
Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins
Sign Up to like & getrecommendations! Published in 2018 at "Biogerontology"
DOI: 10.1007/s10522-018-09792-0
Abstract: Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal ageing. The sirtuin family of deacetylases has been implicated in preventing premature ageing;… read more here.
Keywords: cell senescence; inhibition; senescence; tenovin ... See more keywords
Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09825-2
Abstract: Curcumin, a phytochemical present in the spice named turmeric, and one of the promising anti-aging factors, is itself able to induce cellular senescence. We have recently shown that cells building the vasculature senesced as a… read more here.
Keywords: signaling pathways; cell senescence; vascular smooth; senescence ... See more keywords
Bacterial genotoxins induce T cell senescence.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109220
Abstract: Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms… read more here.
Keywords: induce cell; cell senescence; senescence; genotoxins induce ... See more keywords
Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.09.006
Abstract: ABSTRACT Endothelial cell senescence and Zn nutritional status influence cardiovascular disease. The influence of Zn appears dichotomous, hence it is imperative to understand the relationship with cellular senescence to improve knowledge about the molecular and… read more here.
Keywords: term; cell senescence; endothelial cell; senescence ... See more keywords
The development of cell senescence
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DOI: 10.1016/j.exger.2019.110742
Abstract: Cellular senescence was traditionally considered a stress response that protected the organism by limiting the proliferation of damaged and unwanted cells. However, the recent identification of developmentally-programmed cellular senescence during embryo development has changed our… read more here.
Keywords: development cell; cell senescence; senescence; developmental senescence ... See more keywords
The ING1a model of rapid cell senescence
Sign Up to like & getrecommendations! Published in 2019 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2018.06.004
Abstract: Replicative capacity of normal human cells decreases as telomeric sequence is lost at each division. It is believed that when a subset of chromosomes reach a critically short length, an ATM-initiated and p53-mediated transcriptional response… read more here.
Keywords: senescence; ing1a model; cell senescence;
Tumor cell senescence response produces aggressive variants
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DOI: 10.1038/cddiscovery.2017.49
Abstract: Tumors often respond favorably to initial chemotherapy but eventually relapse with drug resistance and increased metastatic potential. Cellular senescence is a major therapeutic outcome of cancer chemotherapy, which leads to tumor stasis or regression through… read more here.
Keywords: response; cell senescence; senescence; tumor cell ... See more keywords
Cellular senescence and its role in white adipose tissue
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DOI: 10.1038/s41366-021-00757-x
Abstract: Cell senescence is defined as a state of irreversible cell cycle arrest combined with DNA damage and the induction of a senescence-associated secretory phenotype (SASP). This includes increased secretion of many inflammatory agents, proteases, miRNA’s,… read more here.
Keywords: cell senescence; senescence; white adipose; role ... See more keywords
Anti-aging biomaterial sturgeon chondroitin sulfate upregulating anti-oxidant and SIRT-1/c-fos gene expression to reprogram stem cell senescence and prolong longevity.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01997c
Abstract: Aging involves tissue and cell potential dysfunction characterized by stem cell senescence and extracellular matrix microenvironment (ECM) alteration. Chondroitin sulfate (CS), found in the ECM of normal cells and tissues, aids in maintaining tissue homeostasis.… read more here.
Keywords: stem cell; senescence; cell senescence; stem ... See more keywords