CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Cell"
DOI: 10.1016/j.devcel.2017.12.003
Abstract: Summary To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-wide screens to identify positive and negative pathway components and validated top hits using multiple signaling and differentiation assays in two different cell types.… read more here.
Keywords: cell sensitivity; hedgehog; sonic hedgehog; cell ... See more keywords
Reassessing pharmacogenomic cell sensitivity with multilevel statistical models.
Sign Up to like & getrecommendations! Published in 2022 at "Biostatistics"
DOI: 10.1093/biostatistics/kxac010
Abstract: Pharmacogenomic experiments allow for the systematic testing of drugs, at varying dosage concentrations, to study how genomic markers correlate with cell sensitivity to treatment. The first step in the analysis is to quantify the response… read more here.
Keywords: cell; sensitivity; effect; cell sensitivity ... See more keywords