γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release.
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DOI: 10.1053/j.gastro.2021.11.028
Abstract: BACKGROUND & AIMS Excessive shedding of apoptotic enterocytes into the intestinal lumen is observed in inflammatory bowel disease and is correlated with disease relapse. Based on their cytolytic capacity and surveillance behavior, we investigated whether… read more here.
Keywords: release; intraepithelial lymphocytes; microscopy; cd103 ... See more keywords
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
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DOI: 10.1136/gutjnl-2021-325520
Abstract: Objective Increased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising the barrier function.… read more here.
Keywords: cell; cell mechanics; rac1; barrier ... See more keywords
Epithelial RAC1 niches in IBD: from barrier integrity to cytoskeletal plasticity
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DOI: 10.1136/gutjnl-2022-327089
Abstract: The gastrointestinal tract forms the largest contact area with the environment and tightly regulated mechanisms are needed to maintain intestinal homoeostasis. The inner lining of the gastrointestinal tract— the monolayer of intestinal epithelial cells (IECs)—therefore… read more here.
Keywords: microscopy; cell shedding; barrier integrity; cell ... See more keywords
Impact of Epithelial Cell Shedding on Intestinal Homeostasis
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DOI: 10.3390/ijms23084160
Abstract: The gut barrier acts as a first line of defense in the body, and plays a vital role in nutrition and immunoregulation. A layer of epithelial cells bound together via intercellular junction proteins maintains intestinal… read more here.
Keywords: intestinal homeostasis; cell extrusion; cell shedding; epithelial cell ... See more keywords