Helical structure of actin stress fibers and its possible contribution to inducing their direction-selective disassembly upon cell shortening
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-019-01228-z
Abstract: Mechanisms of the assembly of actin stress fibers (SFs) have been extensively studied, while those of the disassembly—particularly cell shortening-induced ones—remain unclear. Here, we show that SFs have helical structures composed of multi-subbundles, and they… read more here.
Keywords: helical structure; upon cell; stress fibers; cell shortening ... See more keywords
TGF‐&bgr;1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0247oc
Abstract: &NA; Transforming growth factor &bgr;1 (TGF‐&bgr;1), a cytokine whose levels are elevated in the airways of patients with asthma, perpetuates airway inflammation and modulates airway structural cell remodeling. However, the role of TGF‐&bgr;1 in excessive… read more here.
Keywords: cell shortening; tgf bgr; bgr; shortening hyperresponsiveness ... See more keywords
PI3K as Mediator of Apoptosis and Contractile Dysfunction in TGFβ1-Stimulated Cardiomyocytes
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DOI: 10.3390/biology10070670
Abstract: Simple Summary TGFβ1 is a growth factor that plays a major role in the remodeling process of the heart by inducing cardiomyocytes dysfunction and apoptosis, as well as fibrosis, thereby restricting heart function. TGFβ1 mediates… read more here.
Keywords: pi3k; apoptosis; dysfunction; tgf ... See more keywords
Uric Acid Deteriorates Load-Free Cell Shortening of Cultured Adult Rat Ventricular Cardiomyocytes via Stimulation of Arginine Turnover
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DOI: 10.3390/biology12010004
Abstract: Simple Summary Uric acid is a metabolite released by cells to detoxify themselves from nitrogen. Unlike other mammalians, hominids, and also birds, lack uricase, an enzyme that catalyzes the transformation of uric acid to allantoin.… read more here.
Keywords: rat; arginine; acid; cell shortening ... See more keywords
Cell Shortening and Calcium Homeostasis Analysis in Adult Cardiomyocytes via a New Software Tool
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030640
Abstract: Intracellular calcium (Ca2+) is the central regulator of heart contractility. Indeed, it couples the electrical signal, which pervades the myocardium, with cardiomyocytes contraction. Moreover, alterations in calcium management are the main factors contributing to the… read more here.
Keywords: tool; analysis; cell shortening; calcium ... See more keywords