Insights into Neurodegeneration in Parkinson's Disease from Single‐Cell and Spatial Genomics
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29374
Abstract: Parkinson's disease (PD) is pathologically defined by the death of dopaminergic (DA) neurons within the pars compacta of the substantia nigra. To date, the cause of this multifaceted disease remains largely unclear, which may contribute… read more here.
Keywords: cell spatial; disease; parkinson disease; single cell ... See more keywords
Palo: spatially aware color palette optimization for single-cell and spatial data
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.03.13.484080
Abstract: Summary In the exploratory data analysis of single-cell or spatial genomic data, single cells or spatial spots are often visualized using a two-dimensional plot where cell clusters or spot clusters are marked with different colors.… read more here.
Keywords: cell; spatially aware; cell spatial; color palette ... See more keywords
TACCO unifies annotation transfer and decomposition of cell identities for single-cell and spatial omics
Sign Up to like & getrecommendations! Published in 2022 at "Nature Biotechnology"
DOI: 10.1101/2022.10.02.508471
Abstract: Transferring annotations of single-cell-, spatial- and multi-omics data is often challenging owing both to technical limitations, such as low spatial resolution or high dropout fraction, and to biological variations, such as continuous spectra of cell… read more here.
Keywords: cell; annotation transfer; cell spatial; single cell ... See more keywords
Single cell‐ and spatial ‘Omics revolutionize physiology
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13848
Abstract: Single cell multi‐ ‘Omics and Spatial Transcriptomics are prominent technological highlights of recent years, and both fields still witness a ceaseless firework of novel approaches for high resolution profiling of additional omics layers. As all… read more here.
Keywords: omics revolutionize; cell spatial; physiology; single cell ... See more keywords
Cellular-scale proximity labeling for recording cell spatial organization in mouse tissues
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg6388
Abstract: Proximity labeling has emerged as a powerful strategy for interrogating cell-cell interactions. However, the nanometer-scale labeling radius impedes the use of current methods for indirect cell communications and makes recording cell spatial organization in tissue… read more here.
Keywords: cell spatial; cell; spatial organization; proximity labeling ... See more keywords
Prison cell spatial density and infectious and communicable diseases: a systematic review
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Open"
DOI: 10.1136/bmjopen-2018-026806
Abstract: Objective To summarise the extent and quality of evidence on the association between prison cell spatial density (a measure of crowding) and infectious and communicable diseases transmission among prisoners. Design Systematic review. Data sources Embase,… read more here.
Keywords: spatial density; prison cell; prison; cell spatial ... See more keywords
Abstract 216: Profiling single cell and spatial transcriptomes in FFPE archived tissues
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-216
Abstract: Single cell and single nuclei RNA sequencing (scRNA-seq and snRNA-seq) have helped to identify cell type and subtypes that are present in complex tissues in both healthy samples and disease states. So far, scRNA-seq and… read more here.
Keywords: cell; archived tissues; profiling single; cell spatial ... See more keywords
Abstract 5648: Single cell spatial phenotyping of bladder tumors with a novel mechanism of NKG2A and HLA-E mediated resistance to BCG immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5648
Abstract: Background: ~75% of diagnosed bladder tumors are non-muscle-invasive, requiring instillation of M. bovis Bacillus Calmette-Guérin (BCG) with recurrence rates observed in ~50% of patients. Treatments for BCG-resistant bladder tumors have lagged because few studies have… read more here.
Keywords: cell; bladder; cell spatial; bladder tumors ... See more keywords
Application of Single-Cell and Spatial Omics in Musculoskeletal Disorder Research
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032271
Abstract: Musculoskeletal disorders, including fractures, scoliosis, heterotopic ossification, osteoporosis, osteoarthritis, disc degeneration, and muscular injury, etc., can occur at any stage of human life. Understanding the occurrence and development mechanism of musculoskeletal disorders, as well as… read more here.
Keywords: cell; cell spatial; single cell; spatial omics ... See more keywords