The structure of myeloid cell‐specific TNF inhibitors affects their biological properties
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13913
Abstract: Spatial organization and conformational changes of antibodies may significantly affect their biological functions. We assessed the effect of mutual organization of the two VHH domains within bispecific antibodies recognizing human TNF and the surface molecules… read more here.
Keywords: tnf; specific tnf; structure myeloid; myeloid cell ... See more keywords
Advanced Biomaterials for Cell-Specific Modulation and Restore of Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202200027
Abstract: The past decade has witnessed the explosive development of cancer immunotherapies. Nevertheless, low immunogenicity, limited specificity, poor delivery efficiency, and off-target side effects remain to be the major limitations for broad implementation of cancer immunotherapies… read more here.
Keywords: cancer; specific modulation; cell specific; cancer immunotherapy ... See more keywords
Perfusion cultures require optimum respiratory ATP supply to maximize cell‐specific and volumetric productivities
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26926
Abstract: Perfusion processes are an emerging alternative to common fed‐batch processes in the growing biopharmaceutical industry. However, the challenge of maintaining high cell‐specific productivities remains. In this study, glucose limitation was applied to two perfusion steady… read more here.
Keywords: cell specific; respiratory atp; atp supply; perfusion ... See more keywords
Cell‐specific targeting of extracellular vesicles though engineering the glycocalyx
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12290
Abstract: Abstract Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity. Available methods to improve the tissue… read more here.
Keywords: extracellular vesicles; evs; specificity; glycocalyx ... See more keywords
Surface-Initiated Synthesis of Cell-Specific Glycopolymers using Live Mammalian Cells as Templates.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200881
Abstract: Molecular recognition is an important process in life activities where specificity is the key. However, the method to gain specificity are often complex and time-consuming. Here, we have developed a novel, versatile and effective way… read more here.
Keywords: cell; initiated synthesis; mammalian cells; specific glycosurfaces ... See more keywords
Cell-Specific Labeling for Analyzing Bidirectional Signaling by Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7154-1_14
Abstract: Cell-specific proteome labeling enables global proteome-wide analysis of cell signaling in heterotypic co-cultures. Such approaches have provided unique insight in contact-initiated receptor tyrosine kinase signaling, transfer of proteomic material between heterotypic cells, and interactions between… read more here.
Keywords: analyzing bidirectional; labeling analyzing; bidirectional signaling; specific labeling ... See more keywords
Identification and Isolation of Novel Sugar-Like RNA Protecting Materials: Glycylglycerins from Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7601-0_24
Abstract: Pluripotent stem cells are a resourceful treasure box for regenerative medicine. They contain a large variety of novel materials useful for designing and developing new medicines and therapies directed against many aging-associated degenerative disorders, including… read more here.
Keywords: rna protecting; stem cell; pluripotent stem; stem ... See more keywords
Analysis of mouse male germ cell-specific or -predominant Tex13 family genes encoding proteins with transcriptional repressor activity
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology Reports"
DOI: 10.1007/s11033-021-06265-5
Abstract: Mammalian spermatogenesis is a highly organized process with successive mitotic, meiotic, and postmeiotic phases. This unique developmental process is characterized by the involvement of spermatogenic cell-specific genes. In this study, we identified and investigated testis… read more here.
Keywords: repressor activity; transcriptional repressor; male germ; activity ... See more keywords
Generation of a Recombinant Stem Cell-Specific Human SOX2 Protein from Escherichia coli Under Native Conditions
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biotechnology"
DOI: 10.1007/s12033-021-00305-y
Abstract: The stem cell-specific SOX2 transcription factor is critical for early embryonic development and the maintenance of embryonic and neural stem cell identity. It is also crucial for the generation of induced pluripotent and neural stem… read more here.
Keywords: protein; stem cell; stem; native conditions ... See more keywords
A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.09.008
Abstract: Multiple sclerosis (MS) is a human neurodegenerative disease characterized by the invasion of autoreactive T cells from the periphery into the CNS. Application of pan-histone deacetylase inhibitors (HDACi) ameliorates experimental autoimmune encephalomyelitis (EAE), an animal… read more here.
Keywords: specific deletion; autoimmune encephalomyelitis; hdac1; cell ... See more keywords
A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.10.013
Abstract: The genome is organized into topologically associated domains (TADs) that enclose smaller subTADs. Here, we identify and characterize an enhancer that is located in the middle of the V gene region of the immunoglobulin kappa… read more here.
Keywords: diverse; repertoire; locus; enhancer ... See more keywords