170 Microfluidics cell squeezing enables potent cellular vaccines in murine models through direct cytosolic loading and direct CD8 T cell priming
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0170
Abstract: Background The presentation of sufficient antigen on major histocompatibility complex class I (MHC-I) is essential to prime CD8+ T cells. Methods To achieve efficient MHC-I presentation, we used microfluidics cell squeezing (Cell Squeeze®) to deliver… read more here.
Keywords: microfluidics cell; cd8; cd8 cells; antigen ... See more keywords
Numerical simulation of cell squeezing through a micropore by the immersed boundary method
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science"
DOI: 10.1177/0954406217730850
Abstract: The deformability of cells has been used as a biomarker to detect circulating tumor cells from patient blood sample using microfluidic devices with microscale pores. Successful separations of circulating tumor cells from a blood sample… read more here.
Keywords: numerical simulation; micropore; simulation cell; cell squeezing ... See more keywords