The maternal‐zygotic transition and zygotic activation of the Mnemiopsis leidyi genome occurs within the first three cleavage cycles
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22926
Abstract: The maternal‐zygotic transition (MZT) describes the developmental reprogramming of gene expression marked by the degradation of maternally supplied gene products and activation of the zygotic genome. While the timing and duration of the MZT vary… read more here.
Keywords: eight cell; maternal zygotic; zygotic transition; cell stage ... See more keywords
Association of Genes Involved in the Circadian Clock With Polysomes in the Bovine Preimplantation Embryo
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DOI: 10.1002/mrd.70054
Abstract: The circadian clock is not functional during preimplantation development because lack of transcription prevents the feedback loop required for circadian cyclicity. Moreover, transcript abundance for the core clock genes (CLOCK, ARNTL, PER1, PER2, CRY1, and… read more here.
Keywords: cell stage; stage; clock; preimplantation embryo ... See more keywords
Isolation, characterization, and expression of proto-oncogene cMyc in large yellow croaker Larimichthys crocea
Sign Up to like & getrecommendations! Published in 2017 at "Fish Physiology and Biochemistry"
DOI: 10.1007/s10695-017-0384-x
Abstract: AbstractcMyc is a vital transcription factor that involves in the regulation of cell proliferation, growth, differentiation, and apoptosis. In the present study, cMyc in Larimichthys crocea (Lc-cMyc) was cloned and analyzed for investigating its function.… read more here.
Keywords: cell stage; larimichthys crocea; expression; cmyc ... See more keywords
Efficient genome editing of two-cell mouse embryos via modified CRISPR/Cas electroporation
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DOI: 10.1038/s41598-024-81198-0
Abstract: Creating genetically modified (GM) animals using CRISPR/Cas mediated through the electroporation of two-cell stage embryos, rather than fertilized eggs, holds considerable potential. The full potential of genome editing using two-cell stage embryos is only beginning… read more here.
Keywords: stage embryos; two cell; cell stage; cell ... See more keywords
44 Analysis of abnormal chromatin configuration induced by inhibiting MEK at the 1-cell stage
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv32n2ab44
Abstract: After fertilisation, mammalian oocytes resume meiosis, leading to pronuclear (PN) formation. It has been known that the mitogen-activated protein kinase pathway negatively regulates PN formation. However, it remains largely unknown how the mitogen-activated protein kinase… read more here.
Keywords: chromatin; mek1 activity; formation; cell stage ... See more keywords
Expression of microRNA let-7 in cleavage embryos modulates cell fate determination and formation of mouse blastocysts
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac181
Abstract: Abstract After fertilization, the zygote undergoes cell division. Up to the 8-cell stage, the blastomeres of mouse preimplantation embryos are morphologically identical. The first cell differentiation starts in the morula leading to the formation of… read more here.
Keywords: cell; let; expression; formation ... See more keywords
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad048
Abstract: Whereas both sperm and egg similarly contribute nuclear genetic material to the zygote of metazoan organisms, the inheritance of other cellular constituents is unequal between the two gametes. Thus, the centriole organelle is contributed solely… read more here.
Keywords: caenorhabditis elegans; sperm contributed; cell stage; contributed centrioles ... See more keywords
P-202 Impact of multinucleation at the two-cell stage on pregnancy outcomes: a day 3 vs. day 5 transfer analysis
Sign Up to like & getrecommendations! Published in 2024 at "Human Reproduction"
DOI: 10.1093/humrep/deae108.572
Abstract: Does multinucleation at the two-cell stage significantly affect pregnancy outcomes, and how does it differ between day 3 and day 5 embryo transfers? Multinucleation at the two-cell stage has a negative effect on pregnancy outcomes… read more here.
Keywords: multinucleation; two cell; cell stage; pregnancy ... See more keywords
Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling
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DOI: 10.1371/journal.pgen.1009294
Abstract: Studies in various animals have shown that asymmetrically localized maternal transcripts play important roles in axial patterning and cell fate specification in early embryos. However, comprehensive analyses of the maternal transcriptomes with spatial information are… read more here.
Keywords: molecular asymmetry; single blastomere; asymmetry cephalochordate; cell stage ... See more keywords
Mouse and human embryonic genome activation initiate at the one-cell stage
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1594995
Abstract: At the moment of their union, fertilizing gametes (sperm and oocyte) are transcriptionally silent: gene expression has to be initiated within the resulting embryo, a process termed embryonic genome activation, EGA. Until recently, EGA was… read more here.
Keywords: embryonic genome; genome activation; cell stage; one cell ... See more keywords