Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.06.012
Abstract: Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma. The diversity… read more here.
Keywords: plasticity cell; evolution; cell state; high plasticity ... See more keywords
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.11.045
Abstract: Summary The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated… read more here.
Keywords: state; transition; cell state; myelinating schwann ... See more keywords
Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102402
Abstract: Summary Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated surface molecules.… read more here.
Keywords: cell state; cdc2; cdc1; conventional dendritic ... See more keywords
TET1 and 5-Hydroxymethylation Preserve the Stem Cell State of Mouse Trophoblast
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.04.009
Abstract: Summary The ten-eleven translocation factor TET1 and its conferred epigenetic modification 5-hydroxymethylcytosine (5hmC) have important roles in maintaining the pluripotent state of embryonic stem cells (ESCs). We previously showed that TET1 is also essential to… read more here.
Keywords: state; cell state; hydroxymethylation; stem cell ... See more keywords
Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-44778-2
Abstract: The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma… read more here.
Keywords: bmal1; clock; cell state; immunity ... See more keywords
VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47985-z
Abstract: Glioblastoma (GBM) is a highly lethal type of cancer. GBM recurrence following chemoradiation is typically attributed to the regrowth of invasive and resistant cells. Therefore, there is a pressing need to gain a deeper understanding… read more here.
Keywords: resistance; cell state; chemoradiation; gbm ... See more keywords
Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59888-8
Abstract: Histologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known about the transcriptional programs that account for their… read more here.
Keywords: expression; cell; cell state; bladder cancer ... See more keywords
A rare PRIMER cell state in plant immunity
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DOI: 10.1038/s41586-024-08383-z
Abstract: Plants lack specialized and mobile immune cells. Consequently, any cell type that encounters pathogens must mount immune responses and communicate with surrounding cells for successful defence. However, the diversity, spatial organization and function of cellular… read more here.
Keywords: cell; plant immunity; cell state; immunity ... See more keywords
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00927-7
Abstract: Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in cancer, often observed independently of genetic heterogeneity, raising the central question of how malignant cell states are encoded epigenetically. To address this, here we… read more here.
Keywords: transcriptional cell; cell state; cell states; heritability ... See more keywords
SOX10 mediates glioblastoma cell-state plasticity
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DOI: 10.1038/s44319-024-00258-8
Abstract: Phenotypic plasticity is a cause of glioblastoma therapy failure. We previously showed that suppressing the oligodendrocyte-lineage regulator SOX10 promotes glioblastoma progression. Here, we analyze SOX10-mediated phenotypic plasticity and exploit it for glioblastoma therapy design. We… read more here.
Keywords: cell state; sox10; stem; glioblastoma ... See more keywords
CStreet: a computed Cell State trajectory inference method for time-series single-cell RNA sequencing data.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab488
Abstract: MOTIVATION The increasing amount of time-series single-cell RNA sequencing (scRNA-seq) data raises the key issue of connecting cell states (i.e., cell clusters or cell types) to obtain the continuous temporal dynamics of transcription, which can… read more here.
Keywords: cell state; cell; cstreet; time series ... See more keywords