Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.06.012
Abstract: Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma. The diversity… read more here.
Keywords: plasticity cell; evolution; cell state; high plasticity ... See more keywords
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.11.045
Abstract: Summary The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated… read more here.
Keywords: state; transition; cell state; myelinating schwann ... See more keywords
Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102402
Abstract: Summary Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated surface molecules.… read more here.
Keywords: cell state; cdc2; cdc1; conventional dendritic ... See more keywords
TET1 and 5-Hydroxymethylation Preserve the Stem Cell State of Mouse Trophoblast
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DOI: 10.1016/j.stemcr.2020.04.009
Abstract: Summary The ten-eleven translocation factor TET1 and its conferred epigenetic modification 5-hydroxymethylcytosine (5hmC) have important roles in maintaining the pluripotent state of embryonic stem cells (ESCs). We previously showed that TET1 is also essential to… read more here.
Keywords: state; cell state; hydroxymethylation; stem cell ... See more keywords
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00927-7
Abstract: Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in cancer, often observed independently of genetic heterogeneity, raising the central question of how malignant cell states are encoded epigenetically. To address this, here we… read more here.
Keywords: transcriptional cell; cell state; cell states; heritability ... See more keywords
CStreet: a computed Cell State trajectory inference method for time-series single-cell RNA sequencing data.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab488
Abstract: MOTIVATION The increasing amount of time-series single-cell RNA sequencing (scRNA-seq) data raises the key issue of connecting cell states (i.e., cell clusters or cell types) to obtain the continuous temporal dynamics of transcription, which can… read more here.
Keywords: cell state; cell; cstreet; time series ... See more keywords
The evolution of the cancer stem cell state in glioblastoma - emerging insights into the next-generation of functional interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa259
Abstract: Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed to a population of self-renewing, therapeutically resistant cancer stem cells (CSCs). Glioblastoma (GBM), the most common primary malignant brain tumor, has been a… read more here.
Keywords: state; cell state; cancer stem; next generation ... See more keywords
Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.09.22.509032
Abstract: Cell state (phenotypic) plasticity is a carefully regulated feature of adult epithelial cells that enables adaptive responses to injury, inflammation, and other forms of stress. Aberrant expansion of the normally restricted capability for cell state… read more here.
Keywords: cell; state; state plasticity; cell state ... See more keywords
Integrated single-cell transcriptomic and epigenetic study of cell state transition and lineage commitment in embryonic mouse cerebellum.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abl9156
Abstract: Recent studies using single-cell RNA-sequencing have revealed cellular heterogeneity in the developing mammalian cerebellum, yet the regulatory logic underlying this cellular diversity remains to be elucidated. Using integrated single-cell RNA and ATAC analyses, we resolved… read more here.
Keywords: cell; state transition; single cell; cerebellum ... See more keywords
Abstract 2229: Cell state transitions shape the intratumoral composition of small cell lung carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2229
Abstract: Introduction: Small cell lung carcinoma (SCLC) is characterized by rapid growth, early metastases, and initial response followed by almost invariable resistance to therapy. Studies to date have not determined the extent that diverse transcriptional programs… read more here.
Keywords: lung carcinoma; cell; state; small cell ... See more keywords
Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-21-0282
Abstract: Abstract Phenotypic plasticity describes the ability of cancer cells to undergo dynamic, nongenetic cell state changes that amplify cancer heterogeneity to promote metastasis and therapy evasion. Thus, cancer cells occupy a continuous spectrum of phenotypic… read more here.
Keywords: cell state; cell; cancer; phenotypic plasticity ... See more keywords