Investigating Cell Fate Decisions with ICGS Analysis of Single Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9224-9_12
Abstract: Advances in single-cell transcriptome profiling have contributed to new insights into the cellular states and underlying regulatory networks that govern lineage commitment. Such cell states include multipotent progenitors that can manifest as mixed-lineage patterns of… read more here.
Keywords: single cell; investigating cell; cell states; biology ... See more keywords
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.08.011
Abstract: Biological heterogeneity in diffuse large B cell lymphoma (DLBCL) is partly driven by cell-of-origin subtypes and associated genomic lesions, but also by diverse cell types and cell states in the tumor microenvironment (TME). However, dissecting… read more here.
Keywords: cell; cell states; large cell; diffuse large ... See more keywords
Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.08.095
Abstract: Signaling networks are nonlinear and complex, involving a large ensemble of dynamic interaction states that fluctuate in space and time. However, therapeutic strategies, such as combination chemotherapy, rarely consider the timing of drug perturbations. If… read more here.
Keywords: dynamic rearrangement; rearrangement cell; drug; cell states ... See more keywords
More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.041
Abstract: Compared to mouse models, less is known about human epidermal cell states and differentiation. In this issue of Cell Reports, Cheng et al. (2018) dissect the cell states and heterogeneity in human epidermis with large-scale transcriptomics… read more here.
Keywords: single cell; parts single; sum parts; cell states ... See more keywords
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48620-7
Abstract: Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of these… read more here.
Keywords: transcriptional cell; chromatin; cell; rheumatoid arthritis ... See more keywords
Integrating single-cell RNA-sequencing and functional assays to decipher mammary cell states and lineage hierarchies
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-020-00175-8
Abstract: The identification and molecular characterization of cellular hierarchies in complex tissues is key to understanding both normal cellular homeostasis and tumorigenesis. The mammary epithelium is a heterogeneous tissue consisting of two main cellular compartments, an… read more here.
Keywords: single cell; cell rna; cell states; rna sequencing ... See more keywords
CD8+ T cell states in human cancer: insights from single-cell analysis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-019-0235-4
Abstract: The T cell infiltrates that are formed in human cancers are a modifier of natural disease progression and also determine the probability of clinical response to cancer immunotherapies. Recent technological advances that allow the single-cell… read more here.
Keywords: single cell; human cancer; cell states; cell analysis ... See more keywords
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
Sign Up to like & getrecommendations! Published in 2019 at "Nature genetics"
DOI: 10.1038/s41588-019-0493-9
Abstract: Immune-disease-associated variants are enriched in active chromatin regions of T cells and macrophages. However, whether these variants function in specific cell states is unknown. Here we stimulated T cells and macrophages in the presence of… read more here.
Keywords: immune disease; cells macrophages; chromatin; disease ... See more keywords
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00927-7
Abstract: Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in cancer, often observed independently of genetic heterogeneity, raising the central question of how malignant cell states are encoded epigenetically. To address this, here we… read more here.
Keywords: transcriptional cell; cell state; cell states; heritability ... See more keywords
MicroRNAs organize intrinsic variation into stem cell states
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1920695117
Abstract: Significance Understanding how mammalian organisms achieve the full diversity of cell types in the adult organism is a central goal of developmental cell biology. Recent work has shown that some embryonic precursor cells can self-organize… read more here.
Keywords: variation; gene expression; cell states; gene ... See more keywords
Deciphering cell states and the cellular ecosystem to improve risk stratification in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaf028
Abstract: Abstract Acute myeloid leukemia (AML) demonstrates significant cellular heterogeneity in both leukemic and immune cells, providing valuable insights into clinical outcomes. Here, we constructed an AML single-cell transcriptome atlas and proposed sciNMF workflow to systematically… read more here.
Keywords: acute myeloid; cell states; cell; cellular ecosystem ... See more keywords