Exosomes from CD133+ cells carrying circ‐ABCC1 mediate cell stemness and metastasis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29600
Abstract: Colorectal cancer (CRC), a fatal tumor, has been diagnosed as one of the most prevalent types of cancers globally, inducing multiple cancer‐linked deaths. Mounting evidence has revealed that circular RNA (circRNA) elicits a regulatory impact… read more here.
Keywords: metastasis; cell stemness; abcc1; circ abcc1 ... See more keywords
Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23388
Abstract: Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer… read more here.
Keywords: gastric cancer; iia; cell stemness; tanshinone iia ... See more keywords
ICAM3 mediates inflammatory signaling to promote cancer cell stemness.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.02.034
Abstract: In this study, we present a medium throughput siRNA screen platform to identify inflammation genes that regulate cancer cell stemness. We identified several novel candidates that decrease OCT4 expression and reduce the ALDH + subpopulation both of… read more here.
Keywords: cancer; icam3 mediates; cell stemness; cancer cell ... See more keywords
Promotion of cancer cell stemness by Ras
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200964
Abstract: Cancer stem cells (CSC) may be the most relevant and elusive cancer cell population, as they have the exquisite ability to seed new tumors. It is plausible, that highly mutated cancer genes, such as KRAS,… read more here.
Keywords: promotion cancer; cancer; cell stemness; cell ... See more keywords
LncRNA LINC00460 takes a stimulating role on hepatocellular carcinoma stemness property.
Sign Up to like & getrecommendations! Published in 2021 at "Cell cycle"
DOI: 10.1080/15384101.2021.1940627
Abstract: Abundant researches have stated that long noncoding RNAs (lncRNAs) are crucial molecules in intricate progression of various cancers in terms of their influence on cell stemness. However, no research has discussed the role of LINC00460… read more here.
Keywords: hepatocellular carcinoma; stemness; linc00460; stemness property ... See more keywords
Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness
Sign Up to like & getrecommendations! Published in 2018 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1414129
Abstract: ABSTRACT The tumor microenvironment harbors cancer-associated fibroblasts that function as major modulators of cancer progression. Here, we assessed to which extent distinct cancer-associated fibroblast subsets impact mammary carcinoma growth and cancer cell stemness in an… read more here.
Keywords: tumor cell; cell stemness; cancer; growth ... See more keywords
The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.2011633
Abstract: ABSTRACT The ubiquitin hydrolase OTUB1 has been elucidated to be highly expressed in tumors, however, its roles in glioma progression are still confusing. Here, via analyzing several online datasets, OTUB1 expression was shown to be… read more here.
Keywords: slc7a11; glioma cell; cell stemness; expression ... See more keywords
Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-1293
Abstract: This study elucidates that de novo expression of MUC5AC promotes cancer cell stemness during Kras-driven pancreatic tumorigenesis and can be targeted for development of a novel therapeutic regimen. Secreted mucin 5AC (MUC5AC) is the most… read more here.
Keywords: muc5ac; cancer; cell stemness; cancer cell ... See more keywords
Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating Bmi-1.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204742
Abstract: B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is overexpressed in various cancer types. We found that Bmi-1 mRNA levels were elevated in nasopharyngeal carcinoma (NPC) cell lines. In immunohistochemical analyses, high Bmi-1 levels… read more here.
Keywords: nasopharyngeal carcinoma; cell; cell stemness; bmi ... See more keywords
Exostosin 1 regulates cancer cell stemness in doxorubicin-resistant breast cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19737
Abstract: Cancer stem cells (CSCs) are associated with cancer recurrence following radio/chemotherapy owing to their high resistance to therapeutic intervention. In this study, we investigated the role of exostoxin 1 (EXT1), an endoplasmic reticulum (ER)-residing type… read more here.
Keywords: cell stemness; cancer cell; cancer; cell ... See more keywords
High RAC3 expression levels are required for induction and maintaining of cancer cell stemness
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23635
Abstract: RAC3 is a transcription coactivator, usually overexpressed in several tumors and required to maintain the pluripotency in normal stem cells. In this work we studied the association between RAC3 overexpression on cancer cell stemness and… read more here.
Keywords: cell stemness; cancer cell; cancer; stem ... See more keywords