Spatiotemporal dynamics of single cell stiffness in the early developing ascidian chordate embryo
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DOI: 10.1038/s42003-021-01869-w
Abstract: During the developmental processes of embryos, cells undergo massive deformation and division that are regulated by mechanical cues. However, little is known about how embryonic cells change their mechanical properties during different cleavage stages. Here,… read more here.
Keywords: single cell; cell stiffness; dynamics single; division ... See more keywords
Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness
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DOI: 10.1128/mbio.01340-18
Abstract: The mechanical properties of bacteria are important for protecting cells against physical stress. The cell wall is the best-characterized cellular element contributing to bacterial cell mechanics; however, the biochemistry underlying its regulation and assembly is… read more here.
Keywords: biochemistry; pseudomonas aeruginosa; cell stiffness; cell ... See more keywords
Cytoskeletal Actin Structure in Osteosarcoma Cells Determines Metastatic Phenotype via Regulating Cell Stiffness, Migration, and Transmigration.
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DOI: 10.3390/cimb43030089
Abstract: Osteosarcoma is the most common primary malignant bone tumor. The cause of death due to osteosarcoma is typically a consequence of metastasis to the lung. Controlling metastasis leads to improved prognosis for osteosarcoma patients. The… read more here.
Keywords: lm8 cells; actin; cell stiffness; osteosarcoma ... See more keywords
A Novel Approach to Reducing Lung Metastasis in Osteosarcoma: Increasing Cell Stiffness with Carbenoxolone
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DOI: 10.3390/cimb45050278
Abstract: Aim: Primary malignant bone tumor osteosarcoma can metastasize to the lung. Diminishing lung metastasis would positively affect the prognosis of patients. Our previous studies demonstrated that highly metastatic osteosarcoma cell lines are significantly softer than… read more here.
Keywords: metastasis; cell; osteosarcoma; cell stiffness ... See more keywords
HIC1 and RassF1A Methylation Attenuates Tubulin Expression and Cell Stiffness in Cancer
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DOI: 10.3390/ijms19102884
Abstract: Cell stiffness is a potential biomarker for monitoring cellular transformation, metastasis, and drug resistance development. Environmental factors relayed into the cell may result in formation of inheritable markers (e.g., DNA methylation), which provide selectable advantages… read more here.
Keywords: methylation; cell stiffness; hic1 rassf1a; expression ... See more keywords