Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2455
Abstract: Recombinant human Acid Alpha Glucosidase (GAA) is the therapeutic enzyme used for the treatment of Pompe disease, a rare genetic disorder characterized by GAA deficiency in the cell lysosomes (Raben et al., Curr Mol Med.… read more here.
Keywords: protein; protease; gaa; cell ... See more keywords
P. falciparum artemisinin resistance: the effect of heme, protein damage, and parasite cell stress response.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00527
Abstract: Despite a significant decline in morbidity and mortality over the last two decades, in 2018 there were 228 million reported cases of malaria and 405,000 malaria-related deaths. Artemisinin, the cornerstone of artemisinin-based combination therapies, is… read more here.
Keywords: protein; heme; artemisinin resistance; resistance ... See more keywords
Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51537-7
Abstract: The impact of chemotherapy on tumor-immune system interaction can be either beneficial or harmful, which is represented by the immunogenic cell death (ICD) paradigm or overexpression of the immunosuppressive protein – programmed death ligand 1… read more here.
Keywords: drug; expression; cancer; cell ... See more keywords
Redox-regulated chaperones in cell stress responses.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221304
Abstract: Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as… read more here.
Keywords: redox regulated; chaperones cell; stress responses; regulated chaperones ... See more keywords
Extracellular cell stress (heat shock) proteins—immune responses and disease: an overview
Sign Up to like & getrecommendations! Published in 2017 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2016.0522
Abstract: Extracellular cell stress proteins are highly conserved phylogenetically and have been shown to act as powerful signalling agonists and receptors for selected ligands in several different settings. They also act as immunostimulatory ‘danger signals’ for… read more here.
Keywords: stress proteins; extracellular cell; heat shock; stress ... See more keywords
Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.72845.1
Abstract: The expression of the calcitonin receptor (CT Receptor) is widespread throughout the life cycle of mammals and in many diseases, and in these contexts the functions of the common isoforms is largely unknown. The relatively… read more here.
Keywords: calcitonin receptor; apoptosis; receptor; cell ... See more keywords