The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26247
Abstract: Neuroblastoma (NB) is a highly malignant pediatric solid tumor where a hypoxic signature correlates with unfavorable patient outcome. The hypoxia‐inducible factor (HIF)‐1α plays an important role in NB progression, contributing to cell proliferation and invasiveness.… read more here.
Keywords: hif; cell survival; rai; physiology ... See more keywords
The Shc protein Rai enhances T‐cell survival under hypoxia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29461
Abstract: Hypoxia occurs in physiological and pathological conditions. T cells experience hypoxia in pathological and physiological conditions as well as in lymphoid organs. Indeed, hypoxia‐inducible factor 1α (HIF‐1α) affects T cell survival and functions. Rai, an… read more here.
Keywords: cell survival; rai; protein rai; hypoxia ... See more keywords
Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target
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DOI: 10.1002/mc.22986
Abstract: Transglutaminase 2 (TG2) has emerged as a key cancer cell survival factor that drives epithelial to mesenchymal transition, angiogenesis, metastasis, inflammation, drug resistance, cancer stem cell survival and stemness, and invasion and migration. TG2 can… read more here.
Keywords: therapy target; survival factor; cell survival; cancer cell ... See more keywords
Theoretical effectiveness of cell survival in fractionated radiotherapy with hypoxia‐targeted dose escalation
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DOI: 10.1002/mp.12177
Abstract: Purpose The goal of this article is to compute the cell survival during fractionated radiotherapy with non‐uniform hypoxia‐targeted dose distribution relative to cell survival for a uniform dose distribution with equal integral tumor dose. The… read more here.
Keywords: uniform dose; cell; dose distributions; cell survival ... See more keywords
A unified multi‐activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS)
Sign Up to like & getrecommendations! Published in 2021 at "Medical Physics"
DOI: 10.1002/mp.14690
Abstract: Purpose Application of linear‐quadratic (LQ) model to large fractional dose treatments is inconsistent with observed cell survival curves having a straight portion at high doses. We have proposed a unified multi‐activation (UMA) model to fit… read more here.
Keywords: survival curves; cell survival; uma model; model ... See more keywords
Cubic membrane formation supports cell survival of amoeba Chaos under starvation-induced stress
Sign Up to like & getrecommendations! Published in 2017 at "Protoplasma"
DOI: 10.1007/s00709-017-1169-x
Abstract: Cubic membranes (CM) are highly organized membrane structures found in biological systems. They are mathematically well defined and reveal a three-dimensional nano-periodic structure with cubic symmetry. These membrane arrangements are frequently induced in cells under… read more here.
Keywords: starvation; cell survival; formation; amoeba chaos ... See more keywords
Pharmacological preconditioning with phosphodiestrase inhibitor: an answer to stem cell survival against ischemic injury through JAK/STAT signaling
Sign Up to like & getrecommendations! Published in 2019 at "Heart Failure Reviews"
DOI: 10.1007/s10741-019-09822-0
Abstract: Stem cell transplantation in regenerative medicine has been widely used in various disorders including cardiovascular diseases (CVD) and emerging next-generation therapy. However, transplanted stem cell encountered ischemia/reperfusion (IR) injury which is a major challenge for… read more here.
Keywords: cell; cell survival; stem cell; pharmacological preconditioning ... See more keywords
TGF-β2 antagonizes IL-6-promoted cell survival
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03595-8
Abstract: Transforming growth factor beta is a key cytokine involved in the pathogenesis of fibrosis in many organs, whereas interleukin-6 plays an important role in the regulation of inflammation. They are both potent angiogenesis inducers with… read more here.
Keywords: antagonizes promoted; cell survival; promoted cell; tgf ... See more keywords
S-Nitrosylation Regulates Cell Survival and Death in the Central Nervous System
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DOI: 10.1007/s11064-017-2303-z
Abstract: Nitric oxide (NO), which is produced from nitric oxide synthase, is an important cell signaling molecule that is crucial for many physiological functions such as neuronal death, neuronal survival, synaptic plasticity, and vascular homeostasis. This… read more here.
Keywords: death; cell survival; nervous system; central nervous ... See more keywords
Quercetin Might Promote Autophagy in a Middle Cerebral Artery Occlusion-Mediated Ischemia Model: Comments on Fawad-Ali Shah et al.
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DOI: 10.1007/s11064-018-2692-7
Abstract: Dear Editor, The recent paper by Fawad-Ali Shah on this journal describes the role of the flavonoid quercetin in a cerebral ischemia model induced in adult Sprague–Dawley male rats by middle cerebral artery occlusion (MCAO)… read more here.
Keywords: cell survival; autophagy; fawad ali; cell ... See more keywords
Increased Retinal Ganglion Cell Survival by Exogenous IL-2 Depends on IL-10, Dopamine D1 Receptors, and Classical IL-2/IL-2R Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03313-1
Abstract: Interleukin-2 (IL-2) is a classical pro-inflammatory cytokine known to display neuroprotective roles in the central nervous system including the retina. In the present study, we investigate the molecular targets involved in the neurotrophic effect of… read more here.
Keywords: cell survival; retinal ganglion; rgc; dopamine receptors ... See more keywords