Site‐Specific Antibody Assembly on Nanoparticles via a Versatile Coating Method for Improved Cell Targeting
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206546
Abstract: Antibody‐nanoparticle conjugates are promising candidates for precision medicine. However, developing a controllable method for conjugating antibodies to nanoparticles without compromising the antibody activity represents a critical challenge. Here, a facile and generalizable film‐coating method is… read more here.
Keywords: cell targeting; nanoparticles via; method; coating method ... See more keywords
d-Fructose-Decorated Poly(ethylene imine) for Human Breast Cancer Cell Targeting.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201600502
Abstract: The high affinity of GLUT5 transporter for d-fructose in breast cancer cells has been discussed intensely. In this contribution, high molar mass linear poly(ethylene imine) (LPEI) is functionalized with d-fructose moieties to combine the selectivity… read more here.
Keywords: breast; cell targeting; breast cancer; poly ethylene ... See more keywords
Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.09.002
Abstract: By the appropriate selection of functional peptides and proper accommodation sites, we have generated a set of multifunctional proteins that combine selectivity for CXCR4+ cell binding and relevant endosomal escape capabilities linked to the viral… read more here.
Keywords: tumor; cell targeting; colorectal cancer; cell ... See more keywords
Endothelial Cell-Targeting, ROS-Ultrasensitive Drug/siRNA Co-Delivery Nanocomplexes Mitigate Early-Stage Neutrophil Recruitment For the Anti-Inflammatory Treatment of Myocardial Ischemia Reperfusion Injury.
Sign Up to like & getrecommendations! Published in 2022 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2022.02.018
Abstract: Neutrophils serve as a key contributor to the pathophysiology of myocardial ischemia reperfusion injury (MIRI), because the unregulated activation and infiltration of neutrophils lead to overwhelming inflammation in the myocardium to cause tissue damage. Herein,… read more here.
Keywords: delivery; endothelial cell; cell targeting; sirna ... See more keywords
Synergistic effects of dendritic cell targeting and laser‐microporation on enhancing epicutaneous skin vaccination efficacy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.09.020
Abstract: ABSTRACT Due to its unique immunological properties, the skin is an attractive target tissue for allergen‐specific immunotherapy. In our current work, we combined a dendritic cell targeting approach with epicutaneous immunization using an ablative fractional… read more here.
Keywords: cell targeting; mannan neoglycoconjugates; laser microporation; dendritic cell ... See more keywords
Methotrexate-plasmid DNA polyplexes for cancer therapy: Characterization, cancer cell targeting ability and tuned in vitro transfection
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.111391
Abstract: Abstract Cell targeting is still the most auspicious task in the design/development of innovative drug and gene delivery systems for advanced biomedical applications. To evolve from conventional delivery vectors, which present several limitations, we report… read more here.
Keywords: cell targeting; plasmid dna; cancer; cancer cell ... See more keywords
Peptide-Functionalized Hydrogel Cubes for Active Tumor Cell Targeting.
Sign Up to like & getrecommendations! Published in 2018 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01088
Abstract: Conjugation of bioactive targeting molecules to nano- or micrometer-sized drug carriers is a pivotal strategy to improve their therapeutic efficiency. Herein, we developed pH- and redox-sensitive hydrogel particles with a surface-conjugated cancer cell targeting ligand… read more here.
Keywords: hydrogel; cell targeting; peptide functionalized; hydrogel cubes ... See more keywords
Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d0cc08073j
Abstract: A series of glycoside-peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis… read more here.
Keywords: ion transport; cell targeting; cancer cell; cancer ... See more keywords
Lupus nephritis and B-cell targeting therapy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2017.1366855
Abstract: ABSTRACT Introduction: Lupus Nephritis (LN) is a severe manifestation of Systemic Lupus Erythematosus (SLE) with a significant prognostic impact. Over a prolonged course, an exhaustion of treatment alternatives may occur and further therapeutic options are… read more here.
Keywords: cell targeting; lupus nephritis; nephritis cell; targeting therapy ... See more keywords
Wanted: An endothelial cell targeting atlas for nanotherapeutic delivery in allograft organs
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Transplantation"
DOI: 10.1111/ajt.17050
Abstract: Despite the profound shortage of organs available for transplant in the U.S., over 5,000 donated organs were declined for use in 2020. Many of these organs were declined due to donor comorbidities or preservation injuries… read more here.
Keywords: atlas nanotherapeutic; targeting atlas; cell targeting; wanted endothelial ... See more keywords
An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale Research Letters"
DOI: 10.1186/s11671-019-3208-3
Abstract: How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles… read more here.
Keywords: targeting drug; efficient cell; delivery system; cell targeting ... See more keywords